Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior
Summary: Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of sensory, motor, and decision inform...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016303 |
| _version_ | 1797375122256953344 |
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| author | Anastasiia Oryshchuk Christos Sourmpis Julie Weverbergh Reza Asri Vahid Esmaeili Alireza Modirshanechi Wulfram Gerstner Carl C.H. Petersen Sylvain Crochet |
| author_facet | Anastasiia Oryshchuk Christos Sourmpis Julie Weverbergh Reza Asri Vahid Esmaeili Alireza Modirshanechi Wulfram Gerstner Carl C.H. Petersen Sylvain Crochet |
| author_sort | Anastasiia Oryshchuk |
| collection | DOAJ |
| description | Summary: Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of sensory, motor, and decision information in the whisker primary somatosensory cortex, medial prefrontal cortex, and tongue-jaw primary motor cortex in mice trained to lick in response to a whisker stimulus with mice that were not taught this association. Irrespective of learning, properties of the sensory stimulus were best encoded in the sensory cortex, whereas fine movement kinematics were best represented in the motor cortex. However, movement initiation and the decision to lick in response to the whisker stimulus were represented in all three areas, with decision neurons in the medial prefrontal cortex being more selective, showing minimal sensory responses in miss trials and motor responses during spontaneous licks. Our results reconcile previous studies indicating highly specific vs. highly distributed sensorimotor processing. |
| first_indexed | 2024-03-08T19:17:39Z |
| format | Article |
| id | doaj.art-87afd8b3c3474b62aecfe75644ae4bb0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T19:17:39Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-87afd8b3c3474b62aecfe75644ae4bb02023-12-27T05:25:41ZengElsevierCell Reports2211-12472024-01-01431113618Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behaviorAnastasiia Oryshchuk0Christos Sourmpis1Julie Weverbergh2Reza Asri3Vahid Esmaeili4Alireza Modirshanechi5Wulfram Gerstner6Carl C.H. Petersen7Sylvain Crochet8Laboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; School of Life Sciences and School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSchool of Life Sciences and School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandSchool of Life Sciences and School of Computer and Communication Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; Corresponding authorLaboratory of Sensory Processing, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; Institut National de la Santé et de la Recherche Médicale (INSERM), 6900 Lyon, France; Corresponding authorSummary: Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of sensory, motor, and decision information in the whisker primary somatosensory cortex, medial prefrontal cortex, and tongue-jaw primary motor cortex in mice trained to lick in response to a whisker stimulus with mice that were not taught this association. Irrespective of learning, properties of the sensory stimulus were best encoded in the sensory cortex, whereas fine movement kinematics were best represented in the motor cortex. However, movement initiation and the decision to lick in response to the whisker stimulus were represented in all three areas, with decision neurons in the medial prefrontal cortex being more selective, showing minimal sensory responses in miss trials and motor responses during spontaneous licks. Our results reconcile previous studies indicating highly specific vs. highly distributed sensorimotor processing.http://www.sciencedirect.com/science/article/pii/S2211124723016303CP: Neuroscience |
| spellingShingle | Anastasiia Oryshchuk Christos Sourmpis Julie Weverbergh Reza Asri Vahid Esmaeili Alireza Modirshanechi Wulfram Gerstner Carl C.H. Petersen Sylvain Crochet Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior Cell Reports CP: Neuroscience |
| title | Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior |
| title_full | Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior |
| title_fullStr | Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior |
| title_full_unstemmed | Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior |
| title_short | Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior |
| title_sort | distributed and specific encoding of sensory motor and decision information in the mouse neocortex during goal directed behavior |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016303 |
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