DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in ma...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/6/e028401.full |
| _version_ | 1818621948816523264 |
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| author | David Westergaard Piotr Jaroslaw Chmura Kaspar Nielsen Lise Thørner Henrik Hjalgrim Helene Paarup Margit Anita Hørup Larsen Mikkel Petersen Poul Jennum Steffen Andersen Mette Nyegaard Gregor Borut Ernst Jemec Thomas Werge Pär I Johansson Erik Sørensen Kristoffer Sølvsten Burgdorf |
| author_facet | David Westergaard Piotr Jaroslaw Chmura Kaspar Nielsen Lise Thørner Henrik Hjalgrim Helene Paarup Margit Anita Hørup Larsen Mikkel Petersen Poul Jennum Steffen Andersen Mette Nyegaard Gregor Borut Ernst Jemec Thomas Werge Pär I Johansson Erik Sørensen Kristoffer Sølvsten Burgdorf |
| author_sort | David Westergaard |
| collection | DOAJ |
| description | PurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. |
| first_indexed | 2024-12-16T18:17:23Z |
| format | Article |
| id | doaj.art-87b0a763dc0842978b871f06d040da92 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-12-16T18:17:23Z |
| publishDate | 2019-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-87b0a763dc0842978b871f06d040da922022-12-21T22:21:39ZengBMJ Publishing GroupBMJ Open2044-60552019-06-019610.1136/bmjopen-2018-028401DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donorsDavid Westergaard0Piotr Jaroslaw Chmura1Kaspar Nielsen2Lise Thørner3Henrik Hjalgrim4Helene Paarup5Margit Anita Hørup Larsen6Mikkel Petersen7Poul Jennum8Steffen Andersen9Mette Nyegaard10Gregor Borut Ernst Jemec11Thomas Werge12Pär I Johansson13Erik Sørensen14Kristoffer Sølvsten Burgdorf152 Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark 2 Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark5 Immunology, Aalborg University Hospital, Aalborg, Denmark6 Immunology, Rigshospitalet, Kobenhavn, Denmark7 Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark 8 Immunology, Odense Universitetshospital, Odense, Denmark6 Immunology, Rigshospitalet, Kobenhavn, Denmark3 Immunology, Aarhus Universitetshospital, Aarhus, Denmark9 Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup Hospital, Copenhagen, Denmark 11 Economics, Copenhagen Business School, Frederiksberg, Denmark12 Biomedicine, Aarhus Universitet Health, Aarhus, Denmark13 Dermatology, Roskilde University Hospital, Roskilde, Denmark14 Clinical Medicine, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark 16 Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark 6 Immunology, Rigshospitalet, Kobenhavn, Denmark6 Immunology, Rigshospitalet, Kobenhavn, DenmarkPurposeTo establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements.ParticipantsBlood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks.Findings to dateThe cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements.Future plansTo provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors.https://bmjopen.bmj.com/content/9/6/e028401.full |
| spellingShingle | David Westergaard Piotr Jaroslaw Chmura Kaspar Nielsen Lise Thørner Henrik Hjalgrim Helene Paarup Margit Anita Hørup Larsen Mikkel Petersen Poul Jennum Steffen Andersen Mette Nyegaard Gregor Borut Ernst Jemec Thomas Werge Pär I Johansson Erik Sørensen Kristoffer Sølvsten Burgdorf DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors BMJ Open |
| title | DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
| title_full | DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
| title_fullStr | DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
| title_full_unstemmed | DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
| title_short | DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors |
| title_sort | dbds genomic cohort a prospective and comprehensive resource for integrative and temporal analysis of genetic environmental and lifestyle factors affecting health of blood donors |
| url | https://bmjopen.bmj.com/content/9/6/e028401.full |
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