Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide

Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide

Purpose: Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low bioavailability of about 15%. The aim was to design mucoadhesive buccal...

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Bibliographic Details
Main Authors: Mitra Jelvehgari, Hadi Valizadeh, Sanam Ziapour, Mahdieh Rahmani, Seyed Hassan Montazam, Saieede Soltani
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2016-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Mucoadhesive;
Buccal
Transmucosal
Sumatriptan
Metoclopramide
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-119.pdf

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