When Oxidative Stress Meets Epigenetics: Implications in Cancer Development
Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/6/468 |
| _version_ | 1797566442220027904 |
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| author | Álvaro García-Guede Olga Vera Inmaculada Ibáñez-de-Caceres |
| author_facet | Álvaro García-Guede Olga Vera Inmaculada Ibáñez-de-Caceres |
| author_sort | Álvaro García-Guede |
| collection | DOAJ |
| description | Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression. |
| first_indexed | 2024-03-10T19:26:53Z |
| format | Article |
| id | doaj.art-87b42d87bcfb4c488933a6e68d4b60cd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T19:26:53Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-87b42d87bcfb4c488933a6e68d4b60cd2023-11-20T02:28:40ZengMDPI AGAntioxidants2076-39212020-06-019646810.3390/antiox9060468When Oxidative Stress Meets Epigenetics: Implications in Cancer DevelopmentÁlvaro García-Guede0Olga Vera1Inmaculada Ibáñez-de-Caceres2Epigenetics Laboratory, INGEMM, Hospital La PAZ. 28046 Madrid, SpainDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USAEpigenetics Laboratory, INGEMM, Hospital La PAZ. 28046 Madrid, SpainCancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Alterations of these gene-expression regulatory elements can be produced by an imbalance of the intracellular environment, such as the one derived by oxidative stress, to promote cancer development, progression, and resistance to chemotherapeutic treatments. Here we review the current literature on the effect of oxidative stress in the epigenetic machinery, especially over the largely unknown ncRNAs and its consequences toward cancer development and progression.https://www.mdpi.com/2076-3921/9/6/468epigeneticscanceroxidative stressmiR7/MAFG/Nrf2 axechemoresistancecancer therapy |
| spellingShingle | Álvaro García-Guede Olga Vera Inmaculada Ibáñez-de-Caceres When Oxidative Stress Meets Epigenetics: Implications in Cancer Development Antioxidants epigenetics cancer oxidative stress miR7/MAFG/Nrf2 axe chemoresistance cancer therapy |
| title | When Oxidative Stress Meets Epigenetics: Implications in Cancer Development |
| title_full | When Oxidative Stress Meets Epigenetics: Implications in Cancer Development |
| title_fullStr | When Oxidative Stress Meets Epigenetics: Implications in Cancer Development |
| title_full_unstemmed | When Oxidative Stress Meets Epigenetics: Implications in Cancer Development |
| title_short | When Oxidative Stress Meets Epigenetics: Implications in Cancer Development |
| title_sort | when oxidative stress meets epigenetics implications in cancer development |
| topic | epigenetics cancer oxidative stress miR7/MAFG/Nrf2 axe chemoresistance cancer therapy |
| url | https://www.mdpi.com/2076-3921/9/6/468 |
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