It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Streptococcus pneumoniae Detection and Pneumococcal Serogroup/Serotype Determination in Carriage

It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Streptococcus pneumoniae Detection and Pneumococcal Serogroup/Serotype Determination in Carriage

BackgroundThe specificity of molecular methods for the detection of Streptococcus pneumoniae carriage is under debate. We propose a procedure for carriage surveillance and vaccine impact studies that increases the accuracy of molecular detection of live pneumococci in polymicrobial respiratory sampl...

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Bibliographic Details
Main Authors: Willem R. Miellet, Janieke van Veldhuizen, David Litt, Rob Mariman, Alienke J. Wijmenga-Monsuur, Paul Badoux, Tessa Nieuwenhuijsen, Rebecca Thombre, Sanaa Mayet, Seyi Eletu, Carmen Sheppard, Marianne Alice van Houten, Nynke Y. Rots, Elizabeth Miller, Norman K. Fry, Elisabeth A. M. Sanders, Krzysztof Trzciński
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
Streptococcus pneumoniae (pneumococcus)
carriage
diagnostic accuracy
qPCR (quantitative PCR)
conventional culture
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.859736/full

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