Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk
Introduction:To date, biomarkers have played a minimal role in the early diagnosis of breast cancer. Although its effects on metabolism are not well known, studies have shown that hypoadiponectinaemia is associated with increased insulin resistance and risk for type-2 diabetes. We aimed to investiga...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-09-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/significantly-lower-serum-adiponectin-levels-in-th/40207
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| _version_ | 1828029112569036800 |
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| author | Turgut Aksoy Didem Can Trabulus Hale Aral Erdinç Serin Canan Kelten Talu |
| author_facet | Turgut Aksoy Didem Can Trabulus Hale Aral Erdinç Serin Canan Kelten Talu |
| author_sort | Turgut Aksoy |
| collection | DOAJ |
| description | Introduction:To date, biomarkers have played a minimal role in the early diagnosis of breast cancer. Although its effects on metabolism are not well known, studies have shown that hypoadiponectinaemia is associated with increased insulin resistance and risk for type-2 diabetes. We aimed to investigate the value of adiponectin together with laboratory results, anthropometric measurements and histopathological findings in assessing the risk of breast cancer and for use in early diagnosis.Methods:In this study, serum samples were obtained from 59 recently diagnosed breast cancer patients and 47 cancerfree controls aged between 22 and 82 years to assay serum adiponectin, lipids, fasting blood glucose and insulin; homeostatic model assessment for insulin resistance (HOMA-IR) and body mass index were calculated using the anthropometric measurements. Histopathologic findings were extracted from the patients’ files.Results:Our results revealed that adiponectin serum levels and HOMA-IR values were significantly different between patients and controls. In addition, serum adiponectin levels were lower in postmenopausal breast cancer patients compared to the controls (p=0.03).Conclusion:In fact, a serum adiponectin level below 4.46 mg/L may be in favour of postmenopausal breast cancer (area under the curve =70%). However, Cerb-B2 expression in patients did not correlate with serum adiponectin levels. These findings have implications for further research on adiponectin as well as the in early diagnosis of postmenopausal breast cancer with possibly higher test sensitivity. |
| first_indexed | 2024-04-10T14:05:45Z |
| format | Article |
| id | doaj.art-87b88858ffda48598ad3796cf19cf0f1 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T14:05:45Z |
| publishDate | 2020-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-87b88858ffda48598ad3796cf19cf0f12023-02-15T16:10:03ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2020-09-0121535536110.4274/imj.galenos.2020.9297913049054Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer RiskTurgut Aksoy0Didem Can Trabulus1Hale Aral2Erdinç Serin3Canan Kelten Talu4 Royal Perth Hospital, University of Western Australia University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of General Surgery, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Medical Biochemistry Laboratory, İstanbul, Turkey İstanbul Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Medical Biochemistry Laboratory, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Clinical Pathology Laboratory, İstanbul, Turkey Introduction:To date, biomarkers have played a minimal role in the early diagnosis of breast cancer. Although its effects on metabolism are not well known, studies have shown that hypoadiponectinaemia is associated with increased insulin resistance and risk for type-2 diabetes. We aimed to investigate the value of adiponectin together with laboratory results, anthropometric measurements and histopathological findings in assessing the risk of breast cancer and for use in early diagnosis.Methods:In this study, serum samples were obtained from 59 recently diagnosed breast cancer patients and 47 cancerfree controls aged between 22 and 82 years to assay serum adiponectin, lipids, fasting blood glucose and insulin; homeostatic model assessment for insulin resistance (HOMA-IR) and body mass index were calculated using the anthropometric measurements. Histopathologic findings were extracted from the patients’ files.Results:Our results revealed that adiponectin serum levels and HOMA-IR values were significantly different between patients and controls. In addition, serum adiponectin levels were lower in postmenopausal breast cancer patients compared to the controls (p=0.03).Conclusion:In fact, a serum adiponectin level below 4.46 mg/L may be in favour of postmenopausal breast cancer (area under the curve =70%). However, Cerb-B2 expression in patients did not correlate with serum adiponectin levels. These findings have implications for further research on adiponectin as well as the in early diagnosis of postmenopausal breast cancer with possibly higher test sensitivity. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/significantly-lower-serum-adiponectin-levels-in-th/40207 adiponectininsulin resistanceearly diagnosis of breast cancerbody mass indexserum lipids |
| spellingShingle | Turgut Aksoy Didem Can Trabulus Hale Aral Erdinç Serin Canan Kelten Talu Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk İstanbul Medical Journal adiponectin insulin resistance early diagnosis of breast cancer body mass index serum lipids |
| title | Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk |
| title_full | Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk |
| title_fullStr | Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk |
| title_full_unstemmed | Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk |
| title_short | Significantly Lower Serum Adiponectin Levels in the Postmenopausal Age may be Specific for Breast Cancer Risk |
| title_sort | significantly lower serum adiponectin levels in the postmenopausal age may be specific for breast cancer risk |
| topic | adiponectin insulin resistance early diagnosis of breast cancer body mass index serum lipids |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/significantly-lower-serum-adiponectin-levels-in-th/40207
|
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