Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons
In the hypothalamus, the arcuate nucleus (ARC) contains AgRP-neurons that regulate energy balance as well as GHRH-neurons that regulate linear growth. Here, the authors looked at how the transcription factors Dlx1/2 and Otp link development of AgRP- and GHRH-neurons.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04377-4 |
| _version_ | 1818834972438429696 |
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| author | Bora Lee Janghyun Kim Taekyeong An Sangsoo Kim Esha M. Patel Jacob Raber Soo-Kyung Lee Seunghee Lee Jae W. Lee |
| author_facet | Bora Lee Janghyun Kim Taekyeong An Sangsoo Kim Esha M. Patel Jacob Raber Soo-Kyung Lee Seunghee Lee Jae W. Lee |
| author_sort | Bora Lee |
| collection | DOAJ |
| description | In the hypothalamus, the arcuate nucleus (ARC) contains AgRP-neurons that regulate energy balance as well as GHRH-neurons that regulate linear growth. Here, the authors looked at how the transcription factors Dlx1/2 and Otp link development of AgRP- and GHRH-neurons. |
| first_indexed | 2024-12-19T02:43:18Z |
| format | Article |
| id | doaj.art-87bb4bf21bac41069518ebbc205fec67 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:43:18Z |
| publishDate | 2018-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-87bb4bf21bac41069518ebbc205fec672022-12-21T20:39:02ZengNature PortfolioNature Communications2041-17232018-05-019111310.1038/s41467-018-04377-4Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neuronsBora Lee0Janghyun Kim1Taekyeong An2Sangsoo Kim3Esha M. Patel4Jacob Raber5Soo-Kyung Lee6Seunghee Lee7Jae W. Lee8Center for Neuroscience, Korea Institute of Science and Technology (KIST)Neuroscience Section, Papé Family Pediatrics Research Center, Department of Pediatrics, Oregon Health and Science UniversityDepartment of Bioinformatics and Life Science, Soongsil UniversityDepartment of Bioinformatics and Life Science, Soongsil UniversityDepartment of Behavioral Neuroscience, Oregon Health and Science UniversityDepartment of Behavioral Neuroscience, Oregon Health and Science UniversityNeuroscience Section, Papé Family Pediatrics Research Center, Department of Pediatrics, Oregon Health and Science UniversityCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National UniversityNeuroscience Section, Papé Family Pediatrics Research Center, Department of Pediatrics, Oregon Health and Science UniversityIn the hypothalamus, the arcuate nucleus (ARC) contains AgRP-neurons that regulate energy balance as well as GHRH-neurons that regulate linear growth. Here, the authors looked at how the transcription factors Dlx1/2 and Otp link development of AgRP- and GHRH-neurons.https://doi.org/10.1038/s41467-018-04377-4 |
| spellingShingle | Bora Lee Janghyun Kim Taekyeong An Sangsoo Kim Esha M. Patel Jacob Raber Soo-Kyung Lee Seunghee Lee Jae W. Lee Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons Nature Communications |
| title | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons |
| title_full | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons |
| title_fullStr | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons |
| title_full_unstemmed | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons |
| title_short | Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons |
| title_sort | dlx1 2 and otp coordinate the production of hypothalamic ghrh and agrp neurons |
| url | https://doi.org/10.1038/s41467-018-04377-4 |
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