Inverse symmetry in complete genomes and whole-genome inverse duplication.
The cause of symmetry is usually subtle, and its study often leads to a deeper understanding of the bearer of the symmetry. To gain insight into the dynamics driving the growth and evolution of genomes, we conducted a comprehensive study of textual symmetries in 786 complete chromosomes. We focused...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2771390?pdf=render |
| _version_ | 1818847152320806912 |
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| author | Sing-Guan Kong Wen-Lang Fan Hong-Da Chen Zi-Ting Hsu Nengji Zhou Bo Zheng Hoong-Chien Lee |
| author_facet | Sing-Guan Kong Wen-Lang Fan Hong-Da Chen Zi-Ting Hsu Nengji Zhou Bo Zheng Hoong-Chien Lee |
| author_sort | Sing-Guan Kong |
| collection | DOAJ |
| description | The cause of symmetry is usually subtle, and its study often leads to a deeper understanding of the bearer of the symmetry. To gain insight into the dynamics driving the growth and evolution of genomes, we conducted a comprehensive study of textual symmetries in 786 complete chromosomes. We focused on symmetry based on our belief that, in spite of their extreme diversity, genomes must share common dynamical principles and mechanisms that drive their growth and evolution, and that the most robust footprints of such dynamics are symmetry related. We found that while complement and reverse symmetries are essentially absent in genomic sequences, inverse-complement plus reverse-symmetry is prevalent in complex patterns in most chromosomes, a vast majority of which have near maximum global inverse symmetry. We also discovered relations that can quantitatively account for the long observed but unexplained phenomenon of -mer skews in genomes. Our results suggest segmental and whole-genome inverse duplications are important mechanisms in genome growth and evolution, probably because they are efficient means by which the genome can exploit its double-stranded structure to enrich its code-inventory. |
| first_indexed | 2024-12-19T05:56:54Z |
| format | Article |
| id | doaj.art-87bca86adaa2409bb0331f72ac8395d7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:56:54Z |
| publishDate | 2009-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-87bca86adaa2409bb0331f72ac8395d72022-12-21T20:33:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-11-01411e755310.1371/journal.pone.0007553Inverse symmetry in complete genomes and whole-genome inverse duplication.Sing-Guan KongWen-Lang FanHong-Da ChenZi-Ting HsuNengji ZhouBo ZhengHoong-Chien LeeThe cause of symmetry is usually subtle, and its study often leads to a deeper understanding of the bearer of the symmetry. To gain insight into the dynamics driving the growth and evolution of genomes, we conducted a comprehensive study of textual symmetries in 786 complete chromosomes. We focused on symmetry based on our belief that, in spite of their extreme diversity, genomes must share common dynamical principles and mechanisms that drive their growth and evolution, and that the most robust footprints of such dynamics are symmetry related. We found that while complement and reverse symmetries are essentially absent in genomic sequences, inverse-complement plus reverse-symmetry is prevalent in complex patterns in most chromosomes, a vast majority of which have near maximum global inverse symmetry. We also discovered relations that can quantitatively account for the long observed but unexplained phenomenon of -mer skews in genomes. Our results suggest segmental and whole-genome inverse duplications are important mechanisms in genome growth and evolution, probably because they are efficient means by which the genome can exploit its double-stranded structure to enrich its code-inventory.http://europepmc.org/articles/PMC2771390?pdf=render |
| spellingShingle | Sing-Guan Kong Wen-Lang Fan Hong-Da Chen Zi-Ting Hsu Nengji Zhou Bo Zheng Hoong-Chien Lee Inverse symmetry in complete genomes and whole-genome inverse duplication. PLoS ONE |
| title | Inverse symmetry in complete genomes and whole-genome inverse duplication. |
| title_full | Inverse symmetry in complete genomes and whole-genome inverse duplication. |
| title_fullStr | Inverse symmetry in complete genomes and whole-genome inverse duplication. |
| title_full_unstemmed | Inverse symmetry in complete genomes and whole-genome inverse duplication. |
| title_short | Inverse symmetry in complete genomes and whole-genome inverse duplication. |
| title_sort | inverse symmetry in complete genomes and whole genome inverse duplication |
| url | http://europepmc.org/articles/PMC2771390?pdf=render |
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