Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease
BackgroundThis study investigated whether the fatty liver index (FLI) could predict all-cause mortality and cerebrovascular accident (CVA) during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without substantial liver disease.MethodsThe medical rec...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.848121/full |
| _version_ | 1818548240414408704 |
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| author | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Hyun Joon Choi Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee |
| author_facet | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Hyun Joon Choi Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee |
| author_sort | Pil Gyu Park |
| collection | DOAJ |
| description | BackgroundThis study investigated whether the fatty liver index (FLI) could predict all-cause mortality and cerebrovascular accident (CVA) during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without substantial liver disease.MethodsThe medical records of 75 AAV patients with AAV were retrospectively reviewed. An equation for the FLI is as follows: FLI = (e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745)/(1 + e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745) × 100. The cut-offs of the FLI were obtained using the receiver operator characteristic (ROC) curve analysis.ResultsThe mean age at AAV diagnosis was 59.1 years and 42.7% were male. Eight patients (10.7%) died and 8 patients had CVA during follow-up. When the cut-offs of the FLI for all-cause mortality and CVA were set as the FLI ≥ 33.59 and the FLI ≥ 32.31, AAV patients with the FLI over each cut-off exhibited a higher risk for all-cause mortality or CVA than those without (RR 8.633 and 8.129), respectively. In addition, AAV patients with the FLI over each cut-off exhibited a significantly lower cumulative patients’ survival rate or CVA-free survival rate than those without, respectively. In the multivariable Cox analysis, only the FLI ≥ 33.59 at AAV diagnosis was an independent predictor of all-cause mortality during follow-up in AAV patients (HR 10.448).ConclusionThe FLI at AAV diagnosis can be a potential independent predictor of all-cause mortality and CVA during follow-up in AAV patients. We suggest that physicians measure the FLI at AAV diagnosis and pay more attention to those with a high FLI value for prevention of future mortality and CVA. |
| first_indexed | 2024-12-12T08:17:17Z |
| format | Article |
| id | doaj.art-87bd815740f74d8baf60d940d85dd566 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T08:17:17Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-87bd815740f74d8baf60d940d85dd5662022-12-22T00:31:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-06-01910.3389/fcvm.2022.848121848121Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver DiseasePil Gyu Park0Jung Yoon Pyo1Sung Soo Ahn2Hyun Joon Choi3Jason Jungsik Song4Jason Jungsik Song5Yong-Beom Park6Yong-Beom Park7Ji Hye Huh8Sang-Won Lee9Sang-Won Lee10Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Medicine, Yonsei University College of Medicine, Seoul, South KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South KoreaBackgroundThis study investigated whether the fatty liver index (FLI) could predict all-cause mortality and cerebrovascular accident (CVA) during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without substantial liver disease.MethodsThe medical records of 75 AAV patients with AAV were retrospectively reviewed. An equation for the FLI is as follows: FLI = (e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745)/(1 + e0.953×loge(triglycerides)+0.139×BMI+0.718×loge(GGT)+0.053×waistcircumference–15.745) × 100. The cut-offs of the FLI were obtained using the receiver operator characteristic (ROC) curve analysis.ResultsThe mean age at AAV diagnosis was 59.1 years and 42.7% were male. Eight patients (10.7%) died and 8 patients had CVA during follow-up. When the cut-offs of the FLI for all-cause mortality and CVA were set as the FLI ≥ 33.59 and the FLI ≥ 32.31, AAV patients with the FLI over each cut-off exhibited a higher risk for all-cause mortality or CVA than those without (RR 8.633 and 8.129), respectively. In addition, AAV patients with the FLI over each cut-off exhibited a significantly lower cumulative patients’ survival rate or CVA-free survival rate than those without, respectively. In the multivariable Cox analysis, only the FLI ≥ 33.59 at AAV diagnosis was an independent predictor of all-cause mortality during follow-up in AAV patients (HR 10.448).ConclusionThe FLI at AAV diagnosis can be a potential independent predictor of all-cause mortality and CVA during follow-up in AAV patients. We suggest that physicians measure the FLI at AAV diagnosis and pay more attention to those with a high FLI value for prevention of future mortality and CVA.https://www.frontiersin.org/articles/10.3389/fcvm.2022.848121/fullantineutrophil cytoplasmic antibodyvasculitisfatty liver indexmortalitycerebrovascular accident |
| spellingShingle | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Hyun Joon Choi Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease Frontiers in Cardiovascular Medicine antineutrophil cytoplasmic antibody vasculitis fatty liver index mortality cerebrovascular accident |
| title | Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease |
| title_full | Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease |
| title_fullStr | Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease |
| title_full_unstemmed | Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease |
| title_short | Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease |
| title_sort | fatty liver index independently predicts all cause mortality in patients with antineutrophil cytoplasmic antibody associated vasculitis but no substantial liver disease |
| topic | antineutrophil cytoplasmic antibody vasculitis fatty liver index mortality cerebrovascular accident |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.848121/full |
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