Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases
Fatty acids (FAs) have structural and functional diversity. FAs in the heart are closely associated with cardiac function, and their qualitative or quantitative abnormalities lead to the onset and progression of cardiac disease. FAs are important as an energy substrate for the heart, but when in exc...
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MDPI AG
2022-02-01
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author | Hidenori Moriyama Jin Endo Hidehiko Ikura Hiroki Kitakata Mizuki Momoi Yoshiki Shinya Seien Ko Genki Ichihara Takahiro Hiraide Kohsuke Shirakawa Atsushi Anzai Yoshinori Katsumata Motoaki Sano |
author_facet | Hidenori Moriyama Jin Endo Hidehiko Ikura Hiroki Kitakata Mizuki Momoi Yoshiki Shinya Seien Ko Genki Ichihara Takahiro Hiraide Kohsuke Shirakawa Atsushi Anzai Yoshinori Katsumata Motoaki Sano |
author_sort | Hidenori Moriyama |
collection | DOAJ |
description | Fatty acids (FAs) have structural and functional diversity. FAs in the heart are closely associated with cardiac function, and their qualitative or quantitative abnormalities lead to the onset and progression of cardiac disease. FAs are important as an energy substrate for the heart, but when in excess, they exhibit cardio-lipotoxicity that causes cardiac dysfunction or heart failure with preserved ejection fraction. FAs also play a role as part of phospholipids that compose cell membranes, and the changes in mitochondrial phospholipid cardiolipin and the FA composition of plasma membrane phospholipids affect cardiomyocyte survival. In addition, FA metabolites exert a wide variety of bioactivities in the heart as lipid mediators. Recent advances in measurement using mass spectrometry have identified trace amounts of n-3 polyunsaturated fatty acids (PUFAs)-derived bioactive metabolites associated with heart disease. n-3 PUFAs have a variety of cardioprotective effects and have been shown in clinical trials to be effective in cardiovascular diseases, including heart failure. This review outlines the contributions of FAs to cardiac function and pathogenesis of heart diseases from the perspective of three major roles and proposes therapeutic applications and new medical perspectives of FAs represented by n-3 PUFAs. |
first_indexed | 2024-03-09T13:21:29Z |
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id | doaj.art-87bf19040be64889b5877d1c270bb650 |
institution | Directory Open Access Journal |
issn | 2218-1989 |
language | English |
last_indexed | 2024-03-09T13:21:29Z |
publishDate | 2022-02-01 |
publisher | MDPI AG |
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series | Metabolites |
spelling | doaj.art-87bf19040be64889b5877d1c270bb6502023-11-30T21:29:23ZengMDPI AGMetabolites2218-19892022-02-0112321010.3390/metabo12030210Qualitative and Quantitative Effects of Fatty Acids Involved in Heart DiseasesHidenori Moriyama0Jin Endo1Hidehiko Ikura2Hiroki Kitakata3Mizuki Momoi4Yoshiki Shinya5Seien Ko6Genki Ichihara7Takahiro Hiraide8Kohsuke Shirakawa9Atsushi Anzai10Yoshinori Katsumata11Motoaki Sano12Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanDepartment of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-City, Tokyo 160-8582, JapanFatty acids (FAs) have structural and functional diversity. FAs in the heart are closely associated with cardiac function, and their qualitative or quantitative abnormalities lead to the onset and progression of cardiac disease. FAs are important as an energy substrate for the heart, but when in excess, they exhibit cardio-lipotoxicity that causes cardiac dysfunction or heart failure with preserved ejection fraction. FAs also play a role as part of phospholipids that compose cell membranes, and the changes in mitochondrial phospholipid cardiolipin and the FA composition of plasma membrane phospholipids affect cardiomyocyte survival. In addition, FA metabolites exert a wide variety of bioactivities in the heart as lipid mediators. Recent advances in measurement using mass spectrometry have identified trace amounts of n-3 polyunsaturated fatty acids (PUFAs)-derived bioactive metabolites associated with heart disease. n-3 PUFAs have a variety of cardioprotective effects and have been shown in clinical trials to be effective in cardiovascular diseases, including heart failure. This review outlines the contributions of FAs to cardiac function and pathogenesis of heart diseases from the perspective of three major roles and proposes therapeutic applications and new medical perspectives of FAs represented by n-3 PUFAs.https://www.mdpi.com/2218-1989/12/3/210fatty acidheart failurelipid dynamicslipotoxicitylipid dropletcardiolipin |
spellingShingle | Hidenori Moriyama Jin Endo Hidehiko Ikura Hiroki Kitakata Mizuki Momoi Yoshiki Shinya Seien Ko Genki Ichihara Takahiro Hiraide Kohsuke Shirakawa Atsushi Anzai Yoshinori Katsumata Motoaki Sano Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases Metabolites fatty acid heart failure lipid dynamics lipotoxicity lipid droplet cardiolipin |
title | Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases |
title_full | Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases |
title_fullStr | Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases |
title_full_unstemmed | Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases |
title_short | Qualitative and Quantitative Effects of Fatty Acids Involved in Heart Diseases |
title_sort | qualitative and quantitative effects of fatty acids involved in heart diseases |
topic | fatty acid heart failure lipid dynamics lipotoxicity lipid droplet cardiolipin |
url | https://www.mdpi.com/2218-1989/12/3/210 |
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