Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.

Establishment, characterization and chemosensitivity of three mismatch repair deficient cell lines from sporadic and inherited colorectal carcinomas.

BACKGROUND: Colorectal cancer (CRC) represents a morphologic and molecular heterogenic disease. This heterogeneity substantially impairs drug effectiveness and prognosis. The subtype of mismatch repair deficient (MMR-D) CRCs, accounting for about 15% of all cases, shows particular differential respo...

Full description

Bibliographic Details
Main Authors:	Claudia Maletzki, Saskia Stier, Ulrike Gruenert, Michael Gock, Christiane Ostwald, Friedrich Prall, Michael Linnebacher
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3534085?pdf=render

Similar Items

Cryopreservation of human colorectal carcinomas prior to xenografting
by: Krohn Mathias, et al.
Published: (2010-07-01)

Ex-vivo clonally expanded B lymphocytes infiltrating colorectal carcinoma are of mature immunophenotype and produce functional IgG.
by: Claudia Maletzki, et al.
Published: (2012-01-01)

Functional Characterization and Drug Response of Freshly Established Patient-Derived Tumor Models with CpG Island Methylator Phenotype.
by: Claudia Maletzki, et al.
Published: (2015-01-01)

Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentity
by: Ingo Andus, et al.
Published: (2023-05-01)

Colorectal carcinoma tumour budding and podia formation in the xenograft microenvironment.
by: Friedrich Prall, et al.
Published: (2017-01-01)

HROP68: A rare case of medullary pancreatic cancer—characterization and chemosensitivity of the first patient-derived cell line
by: Jens von den Driesch, et al.
Published: (2023-01-01)

Sporadic colorectal polyps and mismatch repair proteins
by: Mahsa Molaei, et al.
Published: (2011-01-01)

DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers
by: Fabian Caja, et al.
Published: (2020-08-01)

Clinicopathological and molecular features of sporadic colorectal cancers with DNA mismatch repair deficiency: A single center experience
by: Ali Koyuncuer, et al.
Published: (2020-12-01)

Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques
by: Simon Deycmar, et al.
Published: (2024-03-01)

Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing
by: Diana Behrens, et al.
Published: (2023-12-01)

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors
by: Inken Salewski, et al.
Published: (2022-12-01)

An MSI tumor specific frameshift mutation in a coding microsatellite of MSH3 encodes for HLA-A0201-restricted CD8+ cytotoxic T cell epitopes.
by: Yvette Garbe, et al.
Published: (2011-01-01)

Mismatch Repair Deficiency and Microsatellite Instability
by: Sandra Schöniger, et al.
Published: (2022-08-01)

RUNX1 Mutations in Inherited and Sporadic Leukemia
by: Dana C. Bellissimo, et al.
Published: (2017-12-01)

Human Colorectal Carcinoma Infiltrating B Lymphocytes Are Active Secretors of the Immunoglobulin Isotypes A, G, and M
by: Christina Susanne Mullins, et al.
Published: (2019-06-01)

Yeast mismatch repair components are required for stable inheritance of gene silencing.
by: Qian Liu, et al.
Published: (2020-05-01)

Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
by: Homfray, T, et al.
Published: (1998)

Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research
by: Christina S. Mullins, et al.
Published: (2019-10-01)

Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors
by: Paula Krone, et al.
Published: (2023-12-01)

Unexplained mismatch repair deficiency: Case closed
by: Ellis L. Eikenboom, et al.
Published: (2023-01-01)

Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors
by: Inken Salewski, et al.
Published: (2021-06-01)

Vaccines for immunoprevention of DNA mismatch repair deficient cancers
by: Steven Lipkin, et al.
Published: (2022-06-01)

Low frequency of mismatch repair deficiency in gallbladder cancer
by: Benjamin Goeppert, et al.
Published: (2019-05-01)

Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors
by: Maria Rasmussen, et al.
Published: (2023-04-01)

Establishment of an organoid model of nasopharyngeal carcinoma and its in vitro chemosensitivity profile
by: WANG Xianwen, et al.
Published: (2020-07-01)

Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
by: Stefan Nicolau, et al.
Published: (2023-01-01)

Practical guidance for mismatch repair-deficiency testing in endometrial cancer
by: Stelloo, E, et al.
Published: (2016)

The Somatic Mutational Landscape of Mismatch Repair Deficient Prostate Cancer
by: Bangwei Fang, et al.
Published: (2023-01-01)

Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability
by: Madhura Deshpande, et al.
Published: (2020-11-01)

Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors
by: Lena Hieggelke, et al.
Published: (2021-12-01)

Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
by: Guillaume Mestrallet, et al.
Published: (2023-07-01)

DNA mismatch repair deficient (dMMR) endometrial cancer
by: Chia-Hao Liu, et al.
Published: (2022-09-01)

The efficiency of neoadjuvant chemotherapy in colon cancer with mismatch repair deficiency
by: Wu Yunlong, et al.
Published: (2023-02-01)

Genotype directed therapy in murine mismatch repair deficient tumors.
by: Melanie H Kucherlapati, et al.
Published: (2013-01-01)

The THE FREQUENCY OF MISMATCH REPAIR DEFICIENCY IN COLORECTAL CARCINOMA DETERMINED BY IMMUNOHISTOCHEMISTRY
by: Maria Naseem, et al.
Published: (2021-08-01)

DNA Mismatch Repair Gene Variant Classification: Evaluating the Utility of Somatic Mutations and Mismatch Repair Deficient Colonic Crypts and Endometrial Glands
by: Romy Walker, et al.
Published: (2023-10-01)

DEEP MULTI-INSTANCE LEARNING FOR PREDICTING MISMATCH REPAIR DEFICIENCY IN COLON BIOPSIES
by: Sasa Andjelkovic, et al.
Published: (2022-01-01)

Genotyping possible polymorphic variants of human mismatch repair genes in healthy Korean individuals and sporadic colorectal cancer patients.
by: Kim, J, et al.
Published: (2004)

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia
by: Zubaidah Saizul, et al.
Published: (2021-07-01)