Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces
Biological membranes constitute an interface between cells and their surroundings and form distinct compartments within the cell. They also host a variety of biomolecules that carry out vital functions including selective transport, signal transduction and cell-cell communication. Due to the vast co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2018.00645/full |
| _version_ | 1818026397260578816 |
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| author | Saziye Yorulmaz Avsar Myrto Kyropoulou Stefano Di Leone Cora-Ann Schoenenberger Wolfgang P. Meier Cornelia G. Palivan |
| author_facet | Saziye Yorulmaz Avsar Myrto Kyropoulou Stefano Di Leone Cora-Ann Schoenenberger Wolfgang P. Meier Cornelia G. Palivan |
| author_sort | Saziye Yorulmaz Avsar |
| collection | DOAJ |
| description | Biological membranes constitute an interface between cells and their surroundings and form distinct compartments within the cell. They also host a variety of biomolecules that carry out vital functions including selective transport, signal transduction and cell-cell communication. Due to the vast complexity and versatility of the different membranes, there is a critical need for simplified and specific model membrane platforms to explore the behaviors of individual biomolecules while preserving their intrinsic function. Information obtained from model membrane platforms should make invaluable contributions to current and emerging technologies in biotechnology, nanotechnology and medicine. Amphiphilic block co-polymers are ideal building blocks to create model membrane platforms with enhanced stability and robustness. They form various supramolecular assemblies, ranging from three-dimensional structures (e.g., micelles, nanoparticles, or vesicles) in aqueous solution to planar polymer membranes on solid supports (e.g., polymer cushioned/tethered membranes,) and membrane-like polymer brushes. Furthermore, polymer micelles and polymersomes can also be immobilized on solid supports to take advantage of a wide range of surface sensitive analytical tools. In this review article, we focus on self-assembled amphiphilic block copolymer platforms that are hosting biomolecules. We present different strategies for harnessing polymer platforms with biomolecules either by integrating proteins or peptides into assemblies or by attaching proteins or DNA to their surface. We will discuss how to obtain synthetic structures on solid supports and their characterization using different surface sensitive analytical tools. Finally, we highlight present and future perspectives of polymer micelles and polymersomes for biomedical applications and those of solid-supported polymer membranes for biosensing. |
| first_indexed | 2024-12-10T04:31:21Z |
| format | Article |
| id | doaj.art-87c1438b366442f8a6ed41dd5a436bda |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-10T04:31:21Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-87c1438b366442f8a6ed41dd5a436bda2022-12-22T02:02:08ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-01-01610.3389/fchem.2018.00645433324Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic InterfacesSaziye Yorulmaz AvsarMyrto KyropoulouStefano Di LeoneCora-Ann SchoenenbergerWolfgang P. MeierCornelia G. PalivanBiological membranes constitute an interface between cells and their surroundings and form distinct compartments within the cell. They also host a variety of biomolecules that carry out vital functions including selective transport, signal transduction and cell-cell communication. Due to the vast complexity and versatility of the different membranes, there is a critical need for simplified and specific model membrane platforms to explore the behaviors of individual biomolecules while preserving their intrinsic function. Information obtained from model membrane platforms should make invaluable contributions to current and emerging technologies in biotechnology, nanotechnology and medicine. Amphiphilic block co-polymers are ideal building blocks to create model membrane platforms with enhanced stability and robustness. They form various supramolecular assemblies, ranging from three-dimensional structures (e.g., micelles, nanoparticles, or vesicles) in aqueous solution to planar polymer membranes on solid supports (e.g., polymer cushioned/tethered membranes,) and membrane-like polymer brushes. Furthermore, polymer micelles and polymersomes can also be immobilized on solid supports to take advantage of a wide range of surface sensitive analytical tools. In this review article, we focus on self-assembled amphiphilic block copolymer platforms that are hosting biomolecules. We present different strategies for harnessing polymer platforms with biomolecules either by integrating proteins or peptides into assemblies or by attaching proteins or DNA to their surface. We will discuss how to obtain synthetic structures on solid supports and their characterization using different surface sensitive analytical tools. Finally, we highlight present and future perspectives of polymer micelles and polymersomes for biomedical applications and those of solid-supported polymer membranes for biosensing.https://www.frontiersin.org/article/10.3389/fchem.2018.00645/fullself-assemblyamphiphilic block copolymersmicellespolymersomessupported polymer membranesbiomolecules conjugation |
| spellingShingle | Saziye Yorulmaz Avsar Myrto Kyropoulou Stefano Di Leone Cora-Ann Schoenenberger Wolfgang P. Meier Cornelia G. Palivan Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces Frontiers in Chemistry self-assembly amphiphilic block copolymers micelles polymersomes supported polymer membranes biomolecules conjugation |
| title | Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces |
| title_full | Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces |
| title_fullStr | Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces |
| title_full_unstemmed | Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces |
| title_short | Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces |
| title_sort | biomolecules turn self assembling amphiphilic block co polymer platforms into biomimetic interfaces |
| topic | self-assembly amphiphilic block copolymers micelles polymersomes supported polymer membranes biomolecules conjugation |
| url | https://www.frontiersin.org/article/10.3389/fchem.2018.00645/full |
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