Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis
Abstract Introduction The skin of patients with atopic dermatitis (AD) is characterised by elevated pH. As a central homeostatic regulator, an increased pH accelerates desquamation and suppresses lipid processing, resulting in diminished skin barrier function. The aim of this study was to determine...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-01-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-023-01084-x |
| _version_ | 1797275859734757376 |
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| author | Paul V. Andrew Abigail Pinnock Anna Poyner Kirsty Brown John Chittock Linda J. Kay Michael J. Cork Simon G. Danby |
| author_facet | Paul V. Andrew Abigail Pinnock Anna Poyner Kirsty Brown John Chittock Linda J. Kay Michael J. Cork Simon G. Danby |
| author_sort | Paul V. Andrew |
| collection | DOAJ |
| description | Abstract Introduction The skin of patients with atopic dermatitis (AD) is characterised by elevated pH. As a central homeostatic regulator, an increased pH accelerates desquamation and suppresses lipid processing, resulting in diminished skin barrier function. The aim of this study was to determine whether a novel zinc lactobionate emollient cream can strengthen the skin barrier by lowering skin surface pH. Methods A double-blind, forearm-controlled cohort study was undertaken in patients with AD. Participants applied the test cream to one forearm and a vehicle cream to the other (randomised allocation) twice daily for 56 days. Skin surface pH and barrier function (primary outcomes) were assessed at baseline and after 28 days and 56 days of treatment, amongst other tests. Results A total of 23 adults with AD completed the study. During and after treatment, a sustained difference in skin surface pH was observed between areas treated with the test cream and vehicle (4.50 ± 0.38 versus 5.25 ± 0.54, respectively, p < 0.0001). This was associated with significantly reduced transepidermal water loss (TEWL) on the test cream treated areas compared with control (9.71 ± 2.47 versus 11.20 ± 3.62 g/m2/h, p = 0.0005). Improvements in skin barrier integrity, skin sensitivity to sodium lauryl sulphate, skin hydration, and chymotrypsin-like protease activity were all observed at sites treated with the test cream compared with the control. Conclusion Maintenance of an acidic skin surface pH and delivery of physiologic lipids are beneficial for skin health and may help improve AD control by reducing sensitivity to irritants and allergens. |
| first_indexed | 2024-03-07T15:19:06Z |
| format | Article |
| id | doaj.art-87c415aba9ee4804b5f0f130131cb024 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-03-07T15:19:06Z |
| publishDate | 2024-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-87c415aba9ee4804b5f0f130131cb0242024-03-05T17:44:58ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722024-01-0114239140810.1007/s13555-023-01084-xMaintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic DermatitisPaul V. Andrew0Abigail Pinnock1Anna Poyner2Kirsty Brown3John Chittock4Linda J. Kay5Michael J. Cork6Simon G. Danby7Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldSheffield Dermatology Research, Division of Clinical Medicine, School of Medicine and Population Health, The University of SheffieldAbstract Introduction The skin of patients with atopic dermatitis (AD) is characterised by elevated pH. As a central homeostatic regulator, an increased pH accelerates desquamation and suppresses lipid processing, resulting in diminished skin barrier function. The aim of this study was to determine whether a novel zinc lactobionate emollient cream can strengthen the skin barrier by lowering skin surface pH. Methods A double-blind, forearm-controlled cohort study was undertaken in patients with AD. Participants applied the test cream to one forearm and a vehicle cream to the other (randomised allocation) twice daily for 56 days. Skin surface pH and barrier function (primary outcomes) were assessed at baseline and after 28 days and 56 days of treatment, amongst other tests. Results A total of 23 adults with AD completed the study. During and after treatment, a sustained difference in skin surface pH was observed between areas treated with the test cream and vehicle (4.50 ± 0.38 versus 5.25 ± 0.54, respectively, p < 0.0001). This was associated with significantly reduced transepidermal water loss (TEWL) on the test cream treated areas compared with control (9.71 ± 2.47 versus 11.20 ± 3.62 g/m2/h, p = 0.0005). Improvements in skin barrier integrity, skin sensitivity to sodium lauryl sulphate, skin hydration, and chymotrypsin-like protease activity were all observed at sites treated with the test cream compared with the control. Conclusion Maintenance of an acidic skin surface pH and delivery of physiologic lipids are beneficial for skin health and may help improve AD control by reducing sensitivity to irritants and allergens.https://doi.org/10.1007/s13555-023-01084-xAcid mantleAtopic dermatitisEczemaEmollientpHSkin barrier |
| spellingShingle | Paul V. Andrew Abigail Pinnock Anna Poyner Kirsty Brown John Chittock Linda J. Kay Michael J. Cork Simon G. Danby Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis Dermatology and Therapy Acid mantle Atopic dermatitis Eczema Emollient pH Skin barrier |
| title | Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis |
| title_full | Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis |
| title_fullStr | Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis |
| title_full_unstemmed | Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis |
| title_short | Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis |
| title_sort | maintenance of an acidic skin surface with a novel zinc lactobionate emollient preparation improves skin barrier function in patients with atopic dermatitis |
| topic | Acid mantle Atopic dermatitis Eczema Emollient pH Skin barrier |
| url | https://doi.org/10.1007/s13555-023-01084-x |
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