Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease
Lipoprotein oxidation may play an important role in the pathogenesis of Alzheimer's Disease (AD), and therefore, we investigated cerebrospinal fluid (CSF) antibodies to oxidized low-density lipoprotein (OxLDL) in patients with AD and other neurodegenerative dementias. IgM and IgG antibody titer...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108003057 |
| _version_ | 1818647970978988032 |
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| author | Jari Kankaanpää S. Pauliina Turunen Virpi Moilanen Sohvi Hörkkö Anne M. Remes |
| author_facet | Jari Kankaanpää S. Pauliina Turunen Virpi Moilanen Sohvi Hörkkö Anne M. Remes |
| author_sort | Jari Kankaanpää |
| collection | DOAJ |
| description | Lipoprotein oxidation may play an important role in the pathogenesis of Alzheimer's Disease (AD), and therefore, we investigated cerebrospinal fluid (CSF) antibodies to oxidized low-density lipoprotein (OxLDL) in patients with AD and other neurodegenerative dementias. IgM and IgG antibody titers to OxLDL were measured in 50 CSF samples and 11 plasma samples using chemiluminescent ELISA. All CSF samples contained IgG antibodies, and also most IgM, binding to OxLDL. CSF antibodies to OxLDL were not related to CSF protein or albumin concentrations or plasma antibodies to OxLDL. Competition immunoassay for specificity demonstrated that about 50% of the CSF IgG binding to OxLDL was inhibited by soluble OxLDL. CSF IgG antibodies to OxLDL were significantly increased in AD patients compared to controls and to patients with frontotemporal lobar degeneration. The role of these antibodies in CSF is unknown and further investigations are needed. |
| first_indexed | 2024-12-17T01:11:00Z |
| format | Article |
| id | doaj.art-87c59ab60eb94c8fbd33f7f2a4276dd6 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T01:11:00Z |
| publishDate | 2009-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-87c59ab60eb94c8fbd33f7f2a4276dd62022-12-21T22:09:09ZengElsevierNeurobiology of Disease1095-953X2009-03-01333467472Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's diseaseJari Kankaanpää0S. Pauliina Turunen1Virpi Moilanen2Sohvi Hörkkö3Anne M. Remes4Department of Neurology, University of Oulu, Oulu, Finland; Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Pharmacology and Toxicology, University of Oulu, Oulu, Finland; Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Neurology, University of Oulu, Oulu, FinlandDepartment of Pharmacology and Toxicology, University of Oulu, Oulu, Finland; Clinical Research Center, Oulu University Hospital, Oulu, FinlandDepartment of Neurology, University of Oulu, Oulu, Finland; Clinical Research Center, Oulu University Hospital, Oulu, Finland; Corresponding author. Department of Neurology, University of Oulu, Box 5000, FIN-90014 Oulu, Finland. Fax: +358 8 3154544.Lipoprotein oxidation may play an important role in the pathogenesis of Alzheimer's Disease (AD), and therefore, we investigated cerebrospinal fluid (CSF) antibodies to oxidized low-density lipoprotein (OxLDL) in patients with AD and other neurodegenerative dementias. IgM and IgG antibody titers to OxLDL were measured in 50 CSF samples and 11 plasma samples using chemiluminescent ELISA. All CSF samples contained IgG antibodies, and also most IgM, binding to OxLDL. CSF antibodies to OxLDL were not related to CSF protein or albumin concentrations or plasma antibodies to OxLDL. Competition immunoassay for specificity demonstrated that about 50% of the CSF IgG binding to OxLDL was inhibited by soluble OxLDL. CSF IgG antibodies to OxLDL were significantly increased in AD patients compared to controls and to patients with frontotemporal lobar degeneration. The role of these antibodies in CSF is unknown and further investigations are needed.http://www.sciencedirect.com/science/article/pii/S0969996108003057Alzheimer's diseaseOxidized LDLAntibodyCerebrospinal fluidDementia |
| spellingShingle | Jari Kankaanpää S. Pauliina Turunen Virpi Moilanen Sohvi Hörkkö Anne M. Remes Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease Neurobiology of Disease Alzheimer's disease Oxidized LDL Antibody Cerebrospinal fluid Dementia |
| title | Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease |
| title_full | Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease |
| title_fullStr | Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease |
| title_full_unstemmed | Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease |
| title_short | Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer's disease |
| title_sort | cerebrospinal fluid antibodies to oxidized ldl are increased in alzheimer s disease |
| topic | Alzheimer's disease Oxidized LDL Antibody Cerebrospinal fluid Dementia |
| url | http://www.sciencedirect.com/science/article/pii/S0969996108003057 |
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