Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats
Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels....
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2022-12-01
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| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/mjhr/vol26/iss3/10/ |
| _version_ | 1828039592432893952 |
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| author | Louis Fabio Jonathan Jusni Valencia Chandra Tena Djuartina Dion Notario Zita Arieselia Linawati Hananta |
| author_facet | Louis Fabio Jonathan Jusni Valencia Chandra Tena Djuartina Dion Notario Zita Arieselia Linawati Hananta |
| author_sort | Louis Fabio Jonathan Jusni |
| collection | DOAJ |
| description | Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels.
Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured.
Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05).
Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels. |
| first_indexed | 2024-04-10T16:44:29Z |
| format | Article |
| id | doaj.art-87c5bf23886d4d0784e3f1aac71fab82 |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-04-10T16:44:29Z |
| publishDate | 2022-12-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-87c5bf23886d4d0784e3f1aac71fab822023-02-08T02:30:52ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562022-12-0126320420910.7454/msk.v26i3.1387Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley RatsLouis Fabio Jonathan Jusni0https://orcid.org/0000-0003-0616-595XValencia Chandra1https://orcid.org/0000-0003-4262-7752Tena Djuartina2https://orcid.org/0000-0002-4281-5852Dion Notario3https://orcid.org/0000-0001-7376-3517Zita Arieselia4https://orcid.org/0000-0002-4945-3022Linawati Hananta5https://orcid.org/0000-0002-2068-4345Medicine Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaMedicine Study Programme, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaDepartment of Anatomy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaDepartment of Pharmacy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaDepartment of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaDepartment of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 12930, IndonesiaBackground: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels. Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured. Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05). Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels.https://scholarhub.ui.ac.id/mjhr/vol26/iss3/10/cholesterolhyperlipidemialactoferrinsprague–dawleytriglyceride |
| spellingShingle | Louis Fabio Jonathan Jusni Valencia Chandra Tena Djuartina Dion Notario Zita Arieselia Linawati Hananta Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats Makara Journal of Health Research cholesterol hyperlipidemia lactoferrin sprague–dawley triglyceride |
| title | Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats |
| title_full | Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats |
| title_fullStr | Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats |
| title_full_unstemmed | Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats |
| title_short | Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats |
| title_sort | potential antihyperlipidemia effect of lactoferrin in hyperlipidemia induced male sprague dawley rats |
| topic | cholesterol hyperlipidemia lactoferrin sprague–dawley triglyceride |
| url | https://scholarhub.ui.ac.id/mjhr/vol26/iss3/10/ |
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