Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire
Soichiro Ogawa,1 Akihisa Hasegawa,1 Shunta Makabe,1 Akifumi Onagi,1 Kanako Matsuoka,1 Emina Kayama,1 Tomoyuki Koguchi,1 Junya Hata,1 Yuichi Sato,1 Hidenori Akaihata,1 Masao Kataoka,1 Nobuhiro Haga,2 Yoshiyuki Kojima1 1Department of Urology, Fukushima Medical University School of Medicine, Fukushima,...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Research and Reports in Urology |
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| Online Access: | https://www.dovepress.com/impacts-of-neoadjuvant-hormonal-therapy-prior-to-robot-assisted-radica-peer-reviewed-fulltext-article-RRU |
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| author | Ogawa S Hasegawa A Makabe S Onagi A Matsuoka K Kayama E Koguchi T Hata J Sato Y Akaihata H Kataoka M Haga N Kojima Y |
| author_facet | Ogawa S Hasegawa A Makabe S Onagi A Matsuoka K Kayama E Koguchi T Hata J Sato Y Akaihata H Kataoka M Haga N Kojima Y |
| author_sort | Ogawa S |
| collection | DOAJ |
| description | Soichiro Ogawa,1 Akihisa Hasegawa,1 Shunta Makabe,1 Akifumi Onagi,1 Kanako Matsuoka,1 Emina Kayama,1 Tomoyuki Koguchi,1 Junya Hata,1 Yuichi Sato,1 Hidenori Akaihata,1 Masao Kataoka,1 Nobuhiro Haga,2 Yoshiyuki Kojima1 1Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan; 2Department of Urology, Fukuoka University Faculty of Medicine, Fukuoka, JapanCorrespondence: Soichiro Ogawa, Department of Urology, Fukushima Medical University School of Medicine, 1, Hikarigaoka, Fukushima, 960-1295, Japan, Tel +81 24 547 1316, Fax +81 24 548 3393, Email soh@fmu.ac.jpPurpose: Neoadjuvant hormonal therapy (HT) before radical prostatectomy (RP) is not recommended by current guidelines in terms of oncological outcomes. Despite this, neoadjuvant HT is sometimes conducted before RP for a small proportion of patients in clinical practice. This study evaluated the impacts of neoadjuvant HT on hormonal- and sexual-related quality of life (QOL) among patients who underwent robot-assisted RP (RARP).Materials and Methods: Participants comprised 470 patients divided into a non-neoadjuvant HT group (n = 408) and a neoadjuvant HT group (n = 62). Hormonal- and sexual-related QOL were measured using the Expanded Prostate Cancer Index Composite (EPIC) questionnaire.Results: Hormonal summary scores at 6 and 9 months, function scores before and 3, 6, and 9 months and bother score at 6 months after RARP were significantly lower in the neoadjuvant HT group than in the non-neoadjuvant HT group. Sexual function scores were decreased in the neoadjuvant HT group compared to the non-neoadjuvant HT group before and 6 months after RARP. In the neoadjuvant HT group, sexual function at 3 months after RARP was significantly worse in patients with > 5 months of neoadjuvant HT than in patients with ≤ 5 months of neoadjuvant HT. Conversely, sexual bother at 3 months after RARP was significantly worse in patients with ≤ 5 months of neoadjuvant HT than in patients with > 5 months of neoadjuvant HT.Conclusion: Vintage neoadjuvant HT prior to RARP should not be recommended due to not only oncological outcomes, but also the impacts on postoperative hormonal- and sexual-related QOL.Keywords: androgen deprivation therapy, Expanded Prostate Cancer Index Composite, quality of life, hormonal therapy, neoadjuvant, robot-assisted radical prostatectomy |
| first_indexed | 2024-12-24T00:53:26Z |
| format | Article |
| id | doaj.art-87c86f500f6f4febaf8ccaa313d4f94a |
| institution | Directory Open Access Journal |
| issn | 2253-2447 |
| language | English |
| last_indexed | 2024-12-24T00:53:26Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Research and Reports in Urology |
| spelling | doaj.art-87c86f500f6f4febaf8ccaa313d4f94a2022-12-21T17:23:32ZengDove Medical PressResearch and Reports in Urology2253-24472022-02-01Volume 14394873059Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported QuestionnaireOgawa SHasegawa AMakabe SOnagi AMatsuoka KKayama EKoguchi THata JSato YAkaihata HKataoka MHaga NKojima YSoichiro Ogawa,1 Akihisa Hasegawa,1 Shunta Makabe,1 Akifumi Onagi,1 Kanako Matsuoka,1 Emina Kayama,1 Tomoyuki Koguchi,1 Junya Hata,1 Yuichi Sato,1 Hidenori Akaihata,1 Masao Kataoka,1 Nobuhiro Haga,2 Yoshiyuki Kojima1 1Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan; 2Department of Urology, Fukuoka University Faculty of Medicine, Fukuoka, JapanCorrespondence: Soichiro Ogawa, Department of Urology, Fukushima Medical University School of Medicine, 1, Hikarigaoka, Fukushima, 960-1295, Japan, Tel +81 24 547 1316, Fax +81 24 548 3393, Email soh@fmu.ac.jpPurpose: Neoadjuvant hormonal therapy (HT) before radical prostatectomy (RP) is not recommended by current guidelines in terms of oncological outcomes. Despite this, neoadjuvant HT is sometimes conducted before RP for a small proportion of patients in clinical practice. This study evaluated the impacts of neoadjuvant HT on hormonal- and sexual-related quality of life (QOL) among patients who underwent robot-assisted RP (RARP).Materials and Methods: Participants comprised 470 patients divided into a non-neoadjuvant HT group (n = 408) and a neoadjuvant HT group (n = 62). Hormonal- and sexual-related QOL were measured using the Expanded Prostate Cancer Index Composite (EPIC) questionnaire.Results: Hormonal summary scores at 6 and 9 months, function scores before and 3, 6, and 9 months and bother score at 6 months after RARP were significantly lower in the neoadjuvant HT group than in the non-neoadjuvant HT group. Sexual function scores were decreased in the neoadjuvant HT group compared to the non-neoadjuvant HT group before and 6 months after RARP. In the neoadjuvant HT group, sexual function at 3 months after RARP was significantly worse in patients with > 5 months of neoadjuvant HT than in patients with ≤ 5 months of neoadjuvant HT. Conversely, sexual bother at 3 months after RARP was significantly worse in patients with ≤ 5 months of neoadjuvant HT than in patients with > 5 months of neoadjuvant HT.Conclusion: Vintage neoadjuvant HT prior to RARP should not be recommended due to not only oncological outcomes, but also the impacts on postoperative hormonal- and sexual-related QOL.Keywords: androgen deprivation therapy, Expanded Prostate Cancer Index Composite, quality of life, hormonal therapy, neoadjuvant, robot-assisted radical prostatectomyhttps://www.dovepress.com/impacts-of-neoadjuvant-hormonal-therapy-prior-to-robot-assisted-radica-peer-reviewed-fulltext-article-RRUandrogen deprivation therapyexpanded prostate cancer index compositequality of lifehormonal therapyneoadjuvantrobot-assisted radical prostatectomy |
| spellingShingle | Ogawa S Hasegawa A Makabe S Onagi A Matsuoka K Kayama E Koguchi T Hata J Sato Y Akaihata H Kataoka M Haga N Kojima Y Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire Research and Reports in Urology androgen deprivation therapy expanded prostate cancer index composite quality of life hormonal therapy neoadjuvant robot-assisted radical prostatectomy |
| title | Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire |
| title_full | Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire |
| title_fullStr | Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire |
| title_full_unstemmed | Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire |
| title_short | Impacts of Neoadjuvant Hormonal Therapy Prior to Robot-Assisted Radical Prostatectomy on Postoperative Hormonal- and Sexual-Related Quality of Life – Assessment by Patient-Reported Questionnaire |
| title_sort | impacts of neoadjuvant hormonal therapy prior to robot assisted radical prostatectomy on postoperative hormonal and sexual related quality of life ndash assessment by patient reported questionnaire |
| topic | androgen deprivation therapy expanded prostate cancer index composite quality of life hormonal therapy neoadjuvant robot-assisted radical prostatectomy |
| url | https://www.dovepress.com/impacts-of-neoadjuvant-hormonal-therapy-prior-to-robot-assisted-radica-peer-reviewed-fulltext-article-RRU |
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