HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study
BackgroundAs a valuable blood glucose measurement, HemoglobinA1c (HbA1c) is of great clinical value for diabetes. However, in previous observational studies, studies on its effect on bone mineral density (BMD) have different results. This study aimed to use Mendelian randomization (MR) to assess the...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.942878/full |
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| author | Xiaoxiao Ji Xiaoxiao Ji Xiaoxiao Ji Jianqiao Hong Jianqiao Hong Jianqiao Hong Zihao Qu Zihao Qu Zihao Qu Weinan Yang Weinan Yang Weinan Yang Yibo Wang Yibo Wang Yibo Wang Jiyan Lin Jiyan Lin Jiyan Lin Congsun Li Congsun Li Congsun Li Jie Wang Jie Wang Jie Wang Haochen Mou Haochen Mou Haochen Mou Mingmin Shi Mingmin Shi Mingmin Shi Chenhe Zhou Chenhe Zhou Chenhe Zhou Wei Wang Wei Wang Wei Wang Changjian Lin Changjian Lin Changjian Lin Shigui Yan Shigui Yan Shigui Yan Haobo Wu Haobo Wu Haobo Wu |
| author_facet | Xiaoxiao Ji Xiaoxiao Ji Xiaoxiao Ji Jianqiao Hong Jianqiao Hong Jianqiao Hong Zihao Qu Zihao Qu Zihao Qu Weinan Yang Weinan Yang Weinan Yang Yibo Wang Yibo Wang Yibo Wang Jiyan Lin Jiyan Lin Jiyan Lin Congsun Li Congsun Li Congsun Li Jie Wang Jie Wang Jie Wang Haochen Mou Haochen Mou Haochen Mou Mingmin Shi Mingmin Shi Mingmin Shi Chenhe Zhou Chenhe Zhou Chenhe Zhou Wei Wang Wei Wang Wei Wang Changjian Lin Changjian Lin Changjian Lin Shigui Yan Shigui Yan Shigui Yan Haobo Wu Haobo Wu Haobo Wu |
| author_sort | Xiaoxiao Ji |
| collection | DOAJ |
| description | BackgroundAs a valuable blood glucose measurement, HemoglobinA1c (HbA1c) is of great clinical value for diabetes. However, in previous observational studies, studies on its effect on bone mineral density (BMD) have different results. This study aimed to use Mendelian randomization (MR) to assess the effect of HbA1c on bone mineral density and fracture risk, and try to further explore whether this association was achieved through glycemic or non-glycemic factors.MethodsTake HbA1c measurement as exposure, and BMD estimated from quantitative heel ultrasounds (eBMD) and bone fractures as outcomes. Two-Sample MR Analysis was conducted to assess the causal effect of HbA1C on heel BMD and risk fracture. Then, we performed the analysis using two subsets of these variants, one related to glycemic measurement and the other to erythrocyte indices.ResultsGenetically increased HbA1C was associated with the lower heel eBMD [odds ratio (OR) 0.91 (95% CI 0.87, 0.96) per %-unit, P = 3 × 10−4(IVW)]. Higher HbA1C was associated with lower heel eBMD when using only erythrocytic variants [OR 0.87 (0.82, 0.93), P=2× 10−5(IVW)]; However, when using only glycemic variants, this casual association does not hold. In further MR analysis, we test the association of erythrocytic traits with heel eBMD.ConclusionOur study revealed the significant causal effect of HbA1c on eBMD, and this causal link might achieve through non-glycemic pathways (erythrocytic indices). |
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| spelling | doaj.art-87ca51b0e4504332b46bf40eea5eb9f22022-12-22T01:29:48ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.942878942878HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization StudyXiaoxiao Ji0Xiaoxiao Ji1Xiaoxiao Ji2Jianqiao Hong3Jianqiao Hong4Jianqiao Hong5Zihao Qu6Zihao Qu7Zihao Qu8Weinan Yang9Weinan Yang10Weinan Yang11Yibo Wang12Yibo Wang13Yibo Wang14Jiyan Lin15Jiyan Lin16Jiyan Lin17Congsun Li18Congsun Li19Congsun Li20Jie Wang21Jie Wang22Jie Wang23Haochen Mou24Haochen Mou25Haochen Mou26Mingmin Shi27Mingmin Shi28Mingmin Shi29Chenhe Zhou30Chenhe Zhou31Chenhe Zhou32Wei Wang33Wei Wang34Wei Wang35Changjian Lin36Changjian Lin37Changjian Lin38Shigui Yan39Shigui Yan40Shigui Yan41Haobo Wu42Haobo Wu43Haobo Wu44Department of Orthopedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaOrthopedics Research Institute of Zhejiang University, Hangzhou, ChinaKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, ChinaBackgroundAs a valuable blood glucose measurement, HemoglobinA1c (HbA1c) is of great clinical value for diabetes. However, in previous observational studies, studies on its effect on bone mineral density (BMD) have different results. This study aimed to use Mendelian randomization (MR) to assess the effect of HbA1c on bone mineral density and fracture risk, and try to further explore whether this association was achieved through glycemic or non-glycemic factors.MethodsTake HbA1c measurement as exposure, and BMD estimated from quantitative heel ultrasounds (eBMD) and bone fractures as outcomes. Two-Sample MR Analysis was conducted to assess the causal effect of HbA1C on heel BMD and risk fracture. Then, we performed the analysis using two subsets of these variants, one related to glycemic measurement and the other to erythrocyte indices.ResultsGenetically increased HbA1C was associated with the lower heel eBMD [odds ratio (OR) 0.91 (95% CI 0.87, 0.96) per %-unit, P = 3 × 10−4(IVW)]. Higher HbA1C was associated with lower heel eBMD when using only erythrocytic variants [OR 0.87 (0.82, 0.93), P=2× 10−5(IVW)]; However, when using only glycemic variants, this casual association does not hold. In further MR analysis, we test the association of erythrocytic traits with heel eBMD.ConclusionOur study revealed the significant causal effect of HbA1c on eBMD, and this causal link might achieve through non-glycemic pathways (erythrocytic indices).https://www.frontiersin.org/articles/10.3389/fendo.2022.942878/fullbone mineral densityhemoglobinA1chemoglobinmendelian randomizationosteoporosis |
| spellingShingle | Xiaoxiao Ji Xiaoxiao Ji Xiaoxiao Ji Jianqiao Hong Jianqiao Hong Jianqiao Hong Zihao Qu Zihao Qu Zihao Qu Weinan Yang Weinan Yang Weinan Yang Yibo Wang Yibo Wang Yibo Wang Jiyan Lin Jiyan Lin Jiyan Lin Congsun Li Congsun Li Congsun Li Jie Wang Jie Wang Jie Wang Haochen Mou Haochen Mou Haochen Mou Mingmin Shi Mingmin Shi Mingmin Shi Chenhe Zhou Chenhe Zhou Chenhe Zhou Wei Wang Wei Wang Wei Wang Changjian Lin Changjian Lin Changjian Lin Shigui Yan Shigui Yan Shigui Yan Haobo Wu Haobo Wu Haobo Wu HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study Frontiers in Endocrinology bone mineral density hemoglobinA1c hemoglobin mendelian randomization osteoporosis |
| title | HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study |
| title_full | HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study |
| title_fullStr | HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study |
| title_full_unstemmed | HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study |
| title_short | HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study |
| title_sort | hemoglobina1c is a risk factor for changes of bone mineral density a mendelian randomization study |
| topic | bone mineral density hemoglobinA1c hemoglobin mendelian randomization osteoporosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.942878/full |
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