Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs
Antimicrobial peptides could inhibit the growth of harmful bacteria and promote the growth performance in weaned piglets. Here, we investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAP) on growth performance, diarrhea rate, intestinal health in nursery Hainan...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1298703/full |
| _version_ | 1797226495643484160 |
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| author | Kun Ouyang Kun Ouyang Ting Chen Ruiping Sun Yali Xie Qi Qi Xiang Li Jie Liu Jie Liu Quanwei Liu Limin Wei Limin Wei |
| author_facet | Kun Ouyang Kun Ouyang Ting Chen Ruiping Sun Yali Xie Qi Qi Xiang Li Jie Liu Jie Liu Quanwei Liu Limin Wei Limin Wei |
| author_sort | Kun Ouyang |
| collection | DOAJ |
| description | Antimicrobial peptides could inhibit the growth of harmful bacteria and promote the growth performance in weaned piglets. Here, we investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAP) on growth performance, diarrhea rate, intestinal health in nursery Hainan piglets. For this, 120 healthy nursery Hainan male piglets (13.29 ± 0.29 kg, 44 days old) were randomly divided into 5 groups—a control (CON) group (fed a basal diet), an antibiotic control (AC) group (fed a basal diet supplemented with 250 mg/kg colistin sulfate); and 3 experimental groups (provided the basal diet supplemented with 250, 500, or 1,000 mg/kg CAP). Pre-feeding lasted 7 days and the official period lasted 40 days. The results showed that compared with the CON group, dietary supplementation of 500 mg/kg CAP had significantly increased the average daily gain (ADG, p < 0.05), while the feed conversion ratio (FCR) and diarrhea rate were markedly reduced (p < 0.05), serum total protein (TP), albumin, IgA, IgM, and globulin concentrations were significantly increased (p < 0.05), where serum aspartate aminotransferase (AST) level was significantly reduced (p < 0.05), and it also increased the villus height and the villus height-to-crypt depth ratio in the jejunum, reduced the serum D-lactic acid concentrations and diamine oxidase activity, and increased the expression level of ZO-1 and occludin in the jejunum and ileum (p < 0.05), the relative abundance of Firmicutes, Lactobacillus, and Limoslactobacillus in the colon were increased (p < 0.05), whereas that of Streptococcus and Escherichia–Shigella were reduced (p < 0.05). These results indicated that dietary supplementation with 500 mg/kg CAP could improve the growth performance, reduce the diarrhea rate, improve the serum immunity, intestinal health of nursery pigs. |
| first_indexed | 2024-04-24T14:25:49Z |
| format | Article |
| id | doaj.art-87cb5068566440129368e1053e27f8f8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T14:25:49Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-87cb5068566440129368e1053e27f8f82024-04-03T04:43:56ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-04-011510.3389/fmicb.2024.12987031298703Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigsKun Ouyang0Kun Ouyang1Ting Chen2Ruiping Sun3Yali Xie4Qi Qi5Xiang Li6Jie Liu7Jie Liu8Quanwei Liu9Limin Wei10Limin Wei11Hainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaCollege of Animal Science, South China Agricultural University, Guangzhou, ChinaCollege of Animal Science, South China Agricultural University, Guangzhou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaSanya Institute, Hainan Academy of Agricultural Sciences (Hainan Experimental Animal Research Center), Sanya, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaHainan Key Laboratory of Tropical Animal Breeding and Epidemic Research, Institute of Animal Husbandry and Veterinary Research, Hainan Academy of Agricultural Sciences, Haikou, ChinaSanya Institute, Hainan Academy of Agricultural Sciences (Hainan Experimental Animal Research Center), Sanya, ChinaAntimicrobial peptides could inhibit the growth of harmful bacteria and promote the growth performance in weaned piglets. Here, we investigated the effects of dietary supplementation with cecropin antimicrobial peptides (CAP) on growth performance, diarrhea rate, intestinal health in nursery Hainan piglets. For this, 120 healthy nursery Hainan male piglets (13.29 ± 0.29 kg, 44 days old) were randomly divided into 5 groups—a control (CON) group (fed a basal diet), an antibiotic control (AC) group (fed a basal diet supplemented with 250 mg/kg colistin sulfate); and 3 experimental groups (provided the basal diet supplemented with 250, 500, or 1,000 mg/kg CAP). Pre-feeding lasted 7 days and the official period lasted 40 days. The results showed that compared with the CON group, dietary supplementation of 500 mg/kg CAP had significantly increased the average daily gain (ADG, p < 0.05), while the feed conversion ratio (FCR) and diarrhea rate were markedly reduced (p < 0.05), serum total protein (TP), albumin, IgA, IgM, and globulin concentrations were significantly increased (p < 0.05), where serum aspartate aminotransferase (AST) level was significantly reduced (p < 0.05), and it also increased the villus height and the villus height-to-crypt depth ratio in the jejunum, reduced the serum D-lactic acid concentrations and diamine oxidase activity, and increased the expression level of ZO-1 and occludin in the jejunum and ileum (p < 0.05), the relative abundance of Firmicutes, Lactobacillus, and Limoslactobacillus in the colon were increased (p < 0.05), whereas that of Streptococcus and Escherichia–Shigella were reduced (p < 0.05). These results indicated that dietary supplementation with 500 mg/kg CAP could improve the growth performance, reduce the diarrhea rate, improve the serum immunity, intestinal health of nursery pigs.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1298703/fullnursery Hainan pigletcecropingrowth performancediarrhea rategut health |
| spellingShingle | Kun Ouyang Kun Ouyang Ting Chen Ruiping Sun Yali Xie Qi Qi Xiang Li Jie Liu Jie Liu Quanwei Liu Limin Wei Limin Wei Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs Frontiers in Microbiology nursery Hainan piglet cecropin growth performance diarrhea rate gut health |
| title | Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs |
| title_full | Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs |
| title_fullStr | Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs |
| title_full_unstemmed | Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs |
| title_short | Effects of dietary cecropin on growth performance, diarrhea rate and intestinal health of nursery Hainan pigs |
| title_sort | effects of dietary cecropin on growth performance diarrhea rate and intestinal health of nursery hainan pigs |
| topic | nursery Hainan piglet cecropin growth performance diarrhea rate gut health |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1298703/full |
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