Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases
Vaccination is significant to control, mitigate, and recover from the destructive effects of coronavirus disease 2019 (COVID-19). The incidence of myocarditis following COVID-19 vaccination has been increasing and growing public concern; however, little is known about it. This study aimed to system...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-07-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8779 |
| _version_ | 1797261376139296768 |
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| author | Pandit Bagus Tri Saputra Roy Bagus Kurniawan Desy Trilistyoati Makhyan Jibril Al Farabi Hendri Susilo Mochamad Yusuf Alsagaff Yudi Her Oktaviono Henry Sutanto Arief Gusnanto Citrawati Dyah Kencono Wungu |
| author_facet | Pandit Bagus Tri Saputra Roy Bagus Kurniawan Desy Trilistyoati Makhyan Jibril Al Farabi Hendri Susilo Mochamad Yusuf Alsagaff Yudi Her Oktaviono Henry Sutanto Arief Gusnanto Citrawati Dyah Kencono Wungu |
| author_sort | Pandit Bagus Tri Saputra |
| collection | DOAJ |
| description |
Vaccination is significant to control, mitigate, and recover from the destructive effects of coronavirus disease 2019 (COVID-19). The incidence of myocarditis following COVID-19 vaccination has been increasing and growing public concern; however, little is known about it. This study aimed to systematically review myocarditis following COVID-19 vaccination. We included studies containing individual patient data of myocarditis following COVID-19 vaccination published between January 1, 2020 and September 7, 2022 and excluded review articles. Joanna Briggs Institute critical appraisals were used for risk of bias assessment. Descriptive and analytic statistics were performed. A total of 121 reports and 43 case series from five databases were included. We identified 396 published cases of myocarditis and observed that the majority of cases was male patients, happened following the second dose of mRNA vaccine administration, and experienced chest pain as a symptom. Previous COVID-19 infection was significantly associated (p < 0.01; OR, 5.74; 95% CI, 2.42–13.64) with the risk of myocarditis following the administration of the first dose, indicating that its primary mechanism is immune-mediated. Moreover, 63 histopathology examinations were dominated by non-infective subtypes. Electrocardiography and cardiac marker combination is a sensitive screening modality. However, cardiac magnetic resonance is a significant noninvasive examination to confirm myocarditis. Endomyocardial biopsy may be considered in confusing and severe cases. Myocarditis following COVID-19 vaccination is relatively benign, with a median length of hospitalization of 5 days, intensive care unit admission of <12%, and mortality of <2%. The majority was treated with nonsteroidal anti-inflammatory drugs, colchicine, and steroids. Surprisingly, deceased cases had characteristics of being female, older age, non-chest pain symptoms, first-dose vaccination, left ventricular ejection fraction of <30%, fulminant myocarditis, and eosinophil infiltrate histopathology.
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| first_indexed | 2024-04-24T23:40:14Z |
| format | Article |
| id | doaj.art-87cd0c1c5ec142638dbf13f218606c39 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:40:14Z |
| publishDate | 2023-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-87cd0c1c5ec142638dbf13f218606c392024-03-15T13:22:31ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-07-0123410.17305/bb.2022.8779Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of casesPandit Bagus Tri Saputra0https://orcid.org/0000-0002-5815-0592Roy Bagus Kurniawan1https://orcid.org/0000-0002-4220-8286Desy Trilistyoati2Makhyan Jibril Al Farabi3Hendri Susilo4https://orcid.org/0000-0002-5603-9487Mochamad Yusuf Alsagaff5Yudi Her Oktaviono6Henry Sutanto7Arief Gusnanto8https://orcid.org/0000-0001-5748-784XCitrawati Dyah Kencono Wungu9https://orcid.org/0000-0001-5180-957XDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga–Dr Soetomo General Academic Hospital, Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga–Dr Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Universitas Airlangga Hospital, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga–Dr Soetomo General Academic Hospital, Surabaya, Indonesia; Department of Cardiology and Vascular Medicine, Universitas Airlangga Hospital, Surabaya, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga–Dr Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, NetherlandsSchool of Mathematics, University of Leeds, Leeds, UKDepartment of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia Vaccination is significant to control, mitigate, and recover from the destructive effects of coronavirus disease 2019 (COVID-19). The incidence of myocarditis following COVID-19 vaccination has been increasing and growing public concern; however, little is known about it. This study aimed to systematically review myocarditis following COVID-19 vaccination. We included studies containing individual patient data of myocarditis following COVID-19 vaccination published between January 1, 2020 and September 7, 2022 and excluded review articles. Joanna Briggs Institute critical appraisals were used for risk of bias assessment. Descriptive and analytic statistics were performed. A total of 121 reports and 43 case series from five databases were included. We identified 396 published cases of myocarditis and observed that the majority of cases was male patients, happened following the second dose of mRNA vaccine administration, and experienced chest pain as a symptom. Previous COVID-19 infection was significantly associated (p < 0.01; OR, 5.74; 95% CI, 2.42–13.64) with the risk of myocarditis following the administration of the first dose, indicating that its primary mechanism is immune-mediated. Moreover, 63 histopathology examinations were dominated by non-infective subtypes. Electrocardiography and cardiac marker combination is a sensitive screening modality. However, cardiac magnetic resonance is a significant noninvasive examination to confirm myocarditis. Endomyocardial biopsy may be considered in confusing and severe cases. Myocarditis following COVID-19 vaccination is relatively benign, with a median length of hospitalization of 5 days, intensive care unit admission of <12%, and mortality of <2%. The majority was treated with nonsteroidal anti-inflammatory drugs, colchicine, and steroids. Surprisingly, deceased cases had characteristics of being female, older age, non-chest pain symptoms, first-dose vaccination, left ventricular ejection fraction of <30%, fulminant myocarditis, and eosinophil infiltrate histopathology. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8779myocarditisCOVID-19 vaccinationvaccineSARS-CoV2side effect |
| spellingShingle | Pandit Bagus Tri Saputra Roy Bagus Kurniawan Desy Trilistyoati Makhyan Jibril Al Farabi Hendri Susilo Mochamad Yusuf Alsagaff Yudi Her Oktaviono Henry Sutanto Arief Gusnanto Citrawati Dyah Kencono Wungu Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases Biomolecules & Biomedicine myocarditis COVID-19 vaccination vaccine SARS-CoV2 side effect |
| title | Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases |
| title_full | Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases |
| title_fullStr | Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases |
| title_full_unstemmed | Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases |
| title_short | Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases |
| title_sort | myocarditis and coronavirus disease 2019 vaccination a systematic review and meta summary of cases |
| topic | myocarditis COVID-19 vaccination vaccine SARS-CoV2 side effect |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8779 |
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