Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach
Introduction. Neuroendocrine breast tumors represent a rare subtype of breast cancer, accounting for less than 1 % of all neuroendocrine neoplasms. Starting from their pathology definition, and going through their prevalence, prognosis and treatment, our knowledge is still really uncertain.Materials...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2021-05-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/584 |
| _version_ | 1797872355709550592 |
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| author | Sh. Kh. Gantsev G. Schaller K. Sh. Gantsev A. N. Plikhta Sh. R. Kzyrgalin R. A. Rustamkhanov |
| author_facet | Sh. Kh. Gantsev G. Schaller K. Sh. Gantsev A. N. Plikhta Sh. R. Kzyrgalin R. A. Rustamkhanov |
| author_sort | Sh. Kh. Gantsev |
| collection | DOAJ |
| description | Introduction. Neuroendocrine breast tumors represent a rare subtype of breast cancer, accounting for less than 1 % of all neuroendocrine neoplasms. Starting from their pathology definition, and going through their prevalence, prognosis and treatment, our knowledge is still really uncertain.Materials and methods. The article presents a rare clinical observation of a neuroendocrine breast tumor. A breast fibroadenoma was diagnosed at the initial diagnosis stage in a private clinic; after a surgical treatment and further morphological study, it was estimated: a diagnosis of Cancer in situ of the left breast T1N0M0, stage I. Next, 3D-conformal remote radiation therapy was performed on the area of the left breast.Results and discussion. After conducting positron emission tomography, multiple metastases were detected in the lymph nodes, bones, and liver. Additionally, micropreparations were consulted at the Federal Reference Center in St. Petersburg and at an independent third-party molecular biological laboratory in Germany (Munich). Given all the instrumental, molecular biological, histological and immunohistochemical studies of the patient, an individual regimen of drug therapy was selected.Conclusion. After 18 months of personalized drug therapy, we observed a positive trend and a significant decrease in metabolic activity according to positron emission tomography. |
| first_indexed | 2024-04-10T00:58:33Z |
| format | Article |
| id | doaj.art-87cd978da44f426393e9be29abe216f4 |
| institution | Directory Open Access Journal |
| issn | 2307-0501 2076-3093 |
| language | English |
| last_indexed | 2024-04-10T00:58:33Z |
| publishDate | 2021-05-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-87cd978da44f426393e9be29abe216f42023-03-13T10:01:10ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932021-05-0111214414810.24060/2076-3093-2021-11-2-144-148429Neuroendocrine Breast Cancer. Clinical Observation. Personalized ApproachSh. Kh. Gantsev0G. Schaller1K. Sh. Gantsev2A. N. Plikhta3Sh. R. Kzyrgalin4R. A. Rustamkhanov5Башкирский государственный медицинский университетИнститут рака грудиБашкирский государственный медицинский университетChemilen UGБашкирский государственный медицинский университетБашкирский государственный медицинский университетIntroduction. Neuroendocrine breast tumors represent a rare subtype of breast cancer, accounting for less than 1 % of all neuroendocrine neoplasms. Starting from their pathology definition, and going through their prevalence, prognosis and treatment, our knowledge is still really uncertain.Materials and methods. The article presents a rare clinical observation of a neuroendocrine breast tumor. A breast fibroadenoma was diagnosed at the initial diagnosis stage in a private clinic; after a surgical treatment and further morphological study, it was estimated: a diagnosis of Cancer in situ of the left breast T1N0M0, stage I. Next, 3D-conformal remote radiation therapy was performed on the area of the left breast.Results and discussion. After conducting positron emission tomography, multiple metastases were detected in the lymph nodes, bones, and liver. Additionally, micropreparations were consulted at the Federal Reference Center in St. Petersburg and at an independent third-party molecular biological laboratory in Germany (Munich). Given all the instrumental, molecular biological, histological and immunohistochemical studies of the patient, an individual regimen of drug therapy was selected.Conclusion. After 18 months of personalized drug therapy, we observed a positive trend and a significant decrease in metabolic activity according to positron emission tomography.https://www.surgonco.ru/jour/article/view/584нейроэндокринные опухолирак грудимолочная железасинаптофизинхромогранин аперсонифицированная лекарственная терапиялучевая терапия |
| spellingShingle | Sh. Kh. Gantsev G. Schaller K. Sh. Gantsev A. N. Plikhta Sh. R. Kzyrgalin R. A. Rustamkhanov Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach Креативная хирургия и онкология нейроэндокринные опухоли рак груди молочная железа синаптофизин хромогранин а персонифицированная лекарственная терапия лучевая терапия |
| title | Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach |
| title_full | Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach |
| title_fullStr | Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach |
| title_full_unstemmed | Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach |
| title_short | Neuroendocrine Breast Cancer. Clinical Observation. Personalized Approach |
| title_sort | neuroendocrine breast cancer clinical observation personalized approach |
| topic | нейроэндокринные опухоли рак груди молочная железа синаптофизин хромогранин а персонифицированная лекарственная терапия лучевая терапия |
| url | https://www.surgonco.ru/jour/article/view/584 |
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