Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy

Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy

Osteoarthritis (OA) is the most prevalent degenerative joint disease in the elderly. Accumulation of evidence has suggested that chondrocyte senescence plays a significant role in OA development. Here, we show that Krüppel-like factor 10 (Klf10), also named TGFβ inducible early gene-1 (TIEG1), is in...

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Bibliographic Details
Main Authors: Jie Shang, Nan Lin, Rong Peng, Ning Jiang, Biao Wu, Baizhou Xing, Shiyuan Lin, Xianghe Xu, Huading Lu
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
osteoarthritis
Klf10
senescence
mitochondria
autophagy
Online Access:https://www.mdpi.com/1420-3049/28/3/924

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