Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging
ObjectiveNeuroimaging meta-analysis identified abnormal neural activity alterations in patients with type 2 diabetes mellitus (T2DM), but there was no consistency or heterogeneity analysis between different brain imaging processing strategies. The aim of this meta-analysis was to determine consisten...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.923310/full |
| _version_ | 1818513362899697664 |
|---|---|
| author | Ze-Yang Li Teng Ma Ying Yu Bo Hu Yu Han Hao Xie Min-Hua Ni Min-Hua Ni Zhu-Hong Chen Yang-Ming Zhang Yu-Xiang Huang Wen-Hua Li Wen Wang Lin-Feng Yan Guang-Bin Cui |
| author_facet | Ze-Yang Li Teng Ma Ying Yu Bo Hu Yu Han Hao Xie Min-Hua Ni Min-Hua Ni Zhu-Hong Chen Yang-Ming Zhang Yu-Xiang Huang Wen-Hua Li Wen Wang Lin-Feng Yan Guang-Bin Cui |
| author_sort | Ze-Yang Li |
| collection | DOAJ |
| description | ObjectiveNeuroimaging meta-analysis identified abnormal neural activity alterations in patients with type 2 diabetes mellitus (T2DM), but there was no consistency or heterogeneity analysis between different brain imaging processing strategies. The aim of this meta-analysis was to determine consistent changes of regional brain functions in T2DM via the indicators obtained by using different post-processing methods.MethodsSince the indicators obtained using varied post-processing methods reflect different neurophysiological and pathological characteristics, we further conducted a coordinate-based meta-analysis (CBMA) of the two categories of neuroimaging literature, which were grouped according to similar data processing methods: one group included regional homogeneity (ReHo), independent component analysis (ICA), and degree centrality (DC) studies, while the other group summarized the literature on amplitude of low-frequency fluctuation (ALFF) and cerebral blood flow (CBF).ResultsThe final meta-analysis included 23 eligible trials with 27 data sets. Compared with the healthy control group, when neuroimaging studies were combined with ReHo, ICA, and DC measurements, the brain activity of the right Rolandic operculum, right supramarginal gyrus, and right superior temporal gyrus in T2DM patients decreased significantly. When neuroimaging studies were combined with ALFF and CBF measurements, there was no clear evidence of differences in the brain function between T2DM and HCs.ConclusionT2DM patients have a series of spontaneous abnormal brain activities, mainly involving brain regions related to learning, memory, and emotion, which provide early biomarkers for clarifying the mechanism of cognitive impairment and neuropsychiatric disorders in diabetes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=247071, PROSPERO [CRD42021247071]. |
| first_indexed | 2024-12-11T00:00:16Z |
| format | Article |
| id | doaj.art-87cfbda36d884e61a3e0274dda66ecc1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T00:00:16Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-87cfbda36d884e61a3e0274dda66ecc12022-12-22T01:28:28ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.923310923310Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimagingZe-Yang Li0Teng Ma1Ying Yu2Bo Hu3Yu Han4Hao Xie5Min-Hua Ni6Min-Hua Ni7Zhu-Hong Chen8Yang-Ming Zhang9Yu-Xiang Huang10Wen-Hua Li11Wen Wang12Lin-Feng Yan13Guang-Bin Cui14Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaFaculty of Medical Technology, Shaanxi University of Chinese Medicine, Xianyang, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaBattalion of the Second Regiment of Cadets of Basic Medicine, Fourth Military Medical University, Xi'an, ChinaBattalion of the Second Regiment of Cadets of Basic Medicine, Fourth Military Medical University, Xi'an, ChinaBattalion of the Second Regiment of Cadets of Basic Medicine, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaObjectiveNeuroimaging meta-analysis identified abnormal neural activity alterations in patients with type 2 diabetes mellitus (T2DM), but there was no consistency or heterogeneity analysis between different brain imaging processing strategies. The aim of this meta-analysis was to determine consistent changes of regional brain functions in T2DM via the indicators obtained by using different post-processing methods.MethodsSince the indicators obtained using varied post-processing methods reflect different neurophysiological and pathological characteristics, we further conducted a coordinate-based meta-analysis (CBMA) of the two categories of neuroimaging literature, which were grouped according to similar data processing methods: one group included regional homogeneity (ReHo), independent component analysis (ICA), and degree centrality (DC) studies, while the other group summarized the literature on amplitude of low-frequency fluctuation (ALFF) and cerebral blood flow (CBF).ResultsThe final meta-analysis included 23 eligible trials with 27 data sets. Compared with the healthy control group, when neuroimaging studies were combined with ReHo, ICA, and DC measurements, the brain activity of the right Rolandic operculum, right supramarginal gyrus, and right superior temporal gyrus in T2DM patients decreased significantly. When neuroimaging studies were combined with ALFF and CBF measurements, there was no clear evidence of differences in the brain function between T2DM and HCs.ConclusionT2DM patients have a series of spontaneous abnormal brain activities, mainly involving brain regions related to learning, memory, and emotion, which provide early biomarkers for clarifying the mechanism of cognitive impairment and neuropsychiatric disorders in diabetes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=247071, PROSPERO [CRD42021247071].https://www.frontiersin.org/articles/10.3389/fneur.2022.923310/fullfunctional neuroimagingtype 2 diabetes mellitusfunctional magnetic resonance imagingmild cognitive impairmentcoordinated-based meta-analysis |
| spellingShingle | Ze-Yang Li Teng Ma Ying Yu Bo Hu Yu Han Hao Xie Min-Hua Ni Min-Hua Ni Zhu-Hong Chen Yang-Ming Zhang Yu-Xiang Huang Wen-Hua Li Wen Wang Lin-Feng Yan Guang-Bin Cui Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging Frontiers in Neurology functional neuroimaging type 2 diabetes mellitus functional magnetic resonance imaging mild cognitive impairment coordinated-based meta-analysis |
| title | Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging |
| title_full | Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging |
| title_fullStr | Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging |
| title_full_unstemmed | Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging |
| title_short | Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging |
| title_sort | changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods a new coordinate based meta analysis of neuroimaging |
| topic | functional neuroimaging type 2 diabetes mellitus functional magnetic resonance imaging mild cognitive impairment coordinated-based meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.923310/full |
| work_keys_str_mv | AT zeyangli changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT tengma changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT yingyu changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT bohu changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT yuhan changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT haoxie changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT minhuani changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT minhuani changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT zhuhongchen changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT yangmingzhang changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT yuxianghuang changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT wenhuali changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT wenwang changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT linfengyan changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging AT guangbincui changesofbrainfunctioninpatientswithtype2diabetesmellitusmeasuredbydifferentanalysismethodsanewcoordinatebasedmetaanalysisofneuroimaging |