Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
Vision: bringing the two sides together A protein regulating gene expression called Vax1 is essential for building the optic chiasm (OC), a brain structure where nerves from the left and right eyes cross to the other side of the brain. Signals from both eyes must be integrated for space and depth pe...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-02-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-00930-4 |
| _version_ | 1797865481581887488 |
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| author | Kwang Wook Min Namsuk Kim Jae Hoon Lee Younghoon Sung Museong Kim Eun Jung Lee Jong-Myeong Kim Jae-Hyun Kim Jaeyoung Lee Wonjin Cho Jee Myung Yang Nury Kim Jaehoon Kim C. Justin Lee Young-Gyun Park Seung-Hee Lee Han-Woong Lee Jin Woo Kim |
| author_facet | Kwang Wook Min Namsuk Kim Jae Hoon Lee Younghoon Sung Museong Kim Eun Jung Lee Jong-Myeong Kim Jae-Hyun Kim Jaeyoung Lee Wonjin Cho Jee Myung Yang Nury Kim Jaehoon Kim C. Justin Lee Young-Gyun Park Seung-Hee Lee Han-Woong Lee Jin Woo Kim |
| author_sort | Kwang Wook Min |
| collection | DOAJ |
| description | Vision: bringing the two sides together A protein regulating gene expression called Vax1 is essential for building the optic chiasm (OC), a brain structure where nerves from the left and right eyes cross to the other side of the brain. Signals from both eyes must be integrated for space and depth perception. Although some cues guiding optic nerve growth are known, those for the OC are not. Jin Woo Kim at the Korea Advanced Institute of Science and Technology, Daejeon, South Korea, and co-workers investigated visual development in mice expressing a mutant Vax1. They found that the mutant Vax1 could not support the optic nerve, which grew slowly and failed to connect to the other side of the brain. Consequently, the mice had impaired depth perception and low vision. These results show the importance of Vax1 for the development of binocular vision. |
| first_indexed | 2024-04-09T23:09:04Z |
| format | Article |
| id | doaj.art-87d1752ad47e4b6aa6c3aa77864aca02 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-04-09T23:09:04Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-87d1752ad47e4b6aa6c3aa77864aca022023-03-22T10:31:28ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-02-0155238540010.1038/s12276-023-00930-4Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutantKwang Wook Min0Namsuk Kim1Jae Hoon Lee2Younghoon Sung3Museong Kim4Eun Jung Lee5Jong-Myeong Kim6Jae-Hyun Kim7Jaeyoung Lee8Wonjin Cho9Jee Myung Yang10Nury Kim11Jaehoon Kim12C. Justin Lee13Young-Gyun Park14Seung-Hee Lee15Han-Woong Lee16Jin Woo Kim17Department of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei UniversityDepartment of Convergence Medicine, University of Ulsan College of MedicineDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Bio & Brain Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Ophthalmology, Dongguk University Ilsan HospitalCenter for Cognition and Sociality, Institute for Basic ScienceDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyCenter for Cognition and Sociality, Institute for Basic ScienceDepartment of Bio & Brain Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei UniversityDepartment of Biological Sciences and KAIST Stem Cell Center, Korea Advanced Institute of Science and TechnologyVision: bringing the two sides together A protein regulating gene expression called Vax1 is essential for building the optic chiasm (OC), a brain structure where nerves from the left and right eyes cross to the other side of the brain. Signals from both eyes must be integrated for space and depth perception. Although some cues guiding optic nerve growth are known, those for the OC are not. Jin Woo Kim at the Korea Advanced Institute of Science and Technology, Daejeon, South Korea, and co-workers investigated visual development in mice expressing a mutant Vax1. They found that the mutant Vax1 could not support the optic nerve, which grew slowly and failed to connect to the other side of the brain. Consequently, the mice had impaired depth perception and low vision. These results show the importance of Vax1 for the development of binocular vision.https://doi.org/10.1038/s12276-023-00930-4 |
| spellingShingle | Kwang Wook Min Namsuk Kim Jae Hoon Lee Younghoon Sung Museong Kim Eun Jung Lee Jong-Myeong Kim Jae-Hyun Kim Jaeyoung Lee Wonjin Cho Jee Myung Yang Nury Kim Jaehoon Kim C. Justin Lee Young-Gyun Park Seung-Hee Lee Han-Woong Lee Jin Woo Kim Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant Experimental and Molecular Medicine |
| title | Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
| title_full | Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
| title_fullStr | Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
| title_full_unstemmed | Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
| title_short | Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant |
| title_sort | visuomotor anomalies in achiasmatic mice expressing a transfer defective vax1 mutant |
| url | https://doi.org/10.1038/s12276-023-00930-4 |
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