Correlation between the morphological signs of tuberculosis and the immune status in HIV infection
Comprehensive morphological examination of surgical and biopsy samples from 148 patients and autopsy specimens from 181 deceased persons was made to determine a correlation between the level of immunosuppression and the microscopic signs of tuberculosis in patients with HIV-associated tuberculosis (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-11-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/304 |
| _version_ | 1797759398888603648 |
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| author | Yu. R. Zyuzya V. N. Zimina Yu. G. Parkhomenko M. V. Alvares Figeroa E. A. Dolgova |
| author_facet | Yu. R. Zyuzya V. N. Zimina Yu. G. Parkhomenko M. V. Alvares Figeroa E. A. Dolgova |
| author_sort | Yu. R. Zyuzya |
| collection | DOAJ |
| description | Comprehensive morphological examination of surgical and biopsy samples from 148 patients and autopsy specimens from 181 deceased persons was made to determine a correlation between the level of immunosuppression and the microscopic signs of tuberculosis in patients with HIV-associated tuberculosis (HIV/TB). A relation was found between the count of CD4+ lymphocytes and the predominant type of a tissue inflammatory reaction. Insidious granulomatous inflammation and a preponderance of alterative and exudative components in the foci of tuberculous inflammation suggested that a delayed-type hypersensitivity response that was typical of tuberculosis gave way to an immediate-type hypersensitivity response and reflected severe immune system dysfunction. The lack of responsiveness of the macroorganism in the virtually complete absence of CD4+ lymphocytes observed during autopsy examination led to the acute progression and generalization of tuberculosis, by affecting all organs and systems. |
| first_indexed | 2024-03-12T18:43:54Z |
| format | Article |
| id | doaj.art-87d1ca6a43fe4bfb8f8c6133f6c02b4b |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T18:43:54Z |
| publishDate | 2014-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-87d1ca6a43fe4bfb8f8c6133f6c02b4b2023-08-02T07:47:57ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-11-010114853304Correlation between the morphological signs of tuberculosis and the immune status in HIV infectionYu. R. Zyuzya0V. N. Zimina1Yu. G. Parkhomenko2M. V. Alvares Figeroa3E. A. Dolgova4ГКУЗ «Московский научно-практический центр борьбы с туберкулезом» Департамента здравоохранения г. Москвы; НИИ фтизиопульмонологии ГБОУ ВПО «Первый МГМУ им. И. М. Сеченова»,ГКУЗ «Московский научно-практический центр борьбы с туберкулезом» Департамента здравоохранения г. МосквыФГБУ «НИИ морфологии человека» РАМН, г. Москва; ГКУЗ «Инфекционная клиническая больница № 2» Департамента здравоохранения г. МосквыГКУЗ «Московский научно-практический центр борьбы с туберкулезом» Департамента здравоохранения г. Москвы; ФБУН «ЦНИИ эпидемиологии» Роспотребнадзора, г. МоскваГКУЗ «Московский научно-практический центр борьбы с туберкулезом» Департамента здравоохранения г. Москвы; ФБУН «ЦНИИ эпидемиологии» Роспотребнадзора, г. МоскваComprehensive morphological examination of surgical and biopsy samples from 148 patients and autopsy specimens from 181 deceased persons was made to determine a correlation between the level of immunosuppression and the microscopic signs of tuberculosis in patients with HIV-associated tuberculosis (HIV/TB). A relation was found between the count of CD4+ lymphocytes and the predominant type of a tissue inflammatory reaction. Insidious granulomatous inflammation and a preponderance of alterative and exudative components in the foci of tuberculous inflammation suggested that a delayed-type hypersensitivity response that was typical of tuberculosis gave way to an immediate-type hypersensitivity response and reflected severe immune system dysfunction. The lack of responsiveness of the macroorganism in the virtually complete absence of CD4+ lymphocytes observed during autopsy examination led to the acute progression and generalization of tuberculosis, by affecting all organs and systems.https://www.tibl-journal.com/jour/article/view/304вич-инфекциятуберкулезпатологическая анатомияиммуносупрессия |
| spellingShingle | Yu. R. Zyuzya V. N. Zimina Yu. G. Parkhomenko M. V. Alvares Figeroa E. A. Dolgova Correlation between the morphological signs of tuberculosis and the immune status in HIV infection Туберкулез и болезни лёгких вич-инфекция туберкулез патологическая анатомия иммуносупрессия |
| title | Correlation between the morphological signs of tuberculosis and the immune status in HIV infection |
| title_full | Correlation between the morphological signs of tuberculosis and the immune status in HIV infection |
| title_fullStr | Correlation between the morphological signs of tuberculosis and the immune status in HIV infection |
| title_full_unstemmed | Correlation between the morphological signs of tuberculosis and the immune status in HIV infection |
| title_short | Correlation between the morphological signs of tuberculosis and the immune status in HIV infection |
| title_sort | correlation between the morphological signs of tuberculosis and the immune status in hiv infection |
| topic | вич-инфекция туберкулез патологическая анатомия иммуносупрессия |
| url | https://www.tibl-journal.com/jour/article/view/304 |
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