Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure
Abstract Background and Aim Anticoagulant users with nonvalvular atrial fibrillation (NVAF) sometimes suffer from gastrointestinal bleeding (GIB) and have difficulty continuing the medication. Left atrial appendage closure (LAAC) has been developed for such situations. We aimed to clarify the clinic...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | JGH Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jgh3.13009 |
| _version_ | 1797321302215753728 |
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| author | Tatsuya Kikuchi Yoshiyasu Kono Koji Nakagawa Hiroyuki Okada Masakazu Miyamoto Yoichi Takaya Shoichiro Hirata Shoko Inoo Sakiko Kuraoka Shotaro Okanoue Katsunori Matsueda Takuya Satomi Kenta Hamada Masaya Iwamuro Seiji Kawano Yoshiro Kawahara |
| author_facet | Tatsuya Kikuchi Yoshiyasu Kono Koji Nakagawa Hiroyuki Okada Masakazu Miyamoto Yoichi Takaya Shoichiro Hirata Shoko Inoo Sakiko Kuraoka Shotaro Okanoue Katsunori Matsueda Takuya Satomi Kenta Hamada Masaya Iwamuro Seiji Kawano Yoshiro Kawahara |
| author_sort | Tatsuya Kikuchi |
| collection | DOAJ |
| description | Abstract Background and Aim Anticoagulant users with nonvalvular atrial fibrillation (NVAF) sometimes suffer from gastrointestinal bleeding (GIB) and have difficulty continuing the medication. Left atrial appendage closure (LAAC) has been developed for such situations. We aimed to clarify the clinical significance of a history of GIB in comparison to other factors in patients who had undergone LAAC. Methods From October 2019 to September 2023, patients with NVAF who underwent LAAC at our hospital were enrolled. We investigated the percentage of patients with a history of GIB who underwent LAAC and compared the incidence of post‐LAAC bleeding in these patients compared to those with other factors. Results A total of 45 patients were included. There were 19 patients (42%) with a history of GIB who underwent LAAC. In a Kaplan–Meier analysis, the cumulative incidence of bleeding complications after LAAC was significantly higher in patients with a history of GIB in comparison to patients with other factors. There were eight cases of post‐LAAC bleeding in total, and seven cases had GIB. Conclusions We need to recognize that GIB is a significant complication in patients who undergo LAAC. The management of GIB by gastroenterologists is essential to the success of LAAC. |
| first_indexed | 2024-03-08T04:56:36Z |
| format | Article |
| id | doaj.art-87d31163b3b44af0a31942133508fd3b |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-03-08T04:56:36Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-87d31163b3b44af0a31942133508fd3b2024-02-07T15:12:06ZengWileyJGH Open2397-90702024-01-0181n/an/a10.1002/jgh3.13009Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closureTatsuya Kikuchi0Yoshiyasu Kono1Koji Nakagawa2Hiroyuki Okada3Masakazu Miyamoto4Yoichi Takaya5Shoichiro Hirata6Shoko Inoo7Sakiko Kuraoka8Shotaro Okanoue9Katsunori Matsueda10Takuya Satomi11Kenta Hamada12Masaya Iwamuro13Seiji Kawano14Yoshiro Kawahara15Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanDepartment of Practical Gastrointestinal Endoscopy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama JapanAbstract Background and Aim Anticoagulant users with nonvalvular atrial fibrillation (NVAF) sometimes suffer from gastrointestinal bleeding (GIB) and have difficulty continuing the medication. Left atrial appendage closure (LAAC) has been developed for such situations. We aimed to clarify the clinical significance of a history of GIB in comparison to other factors in patients who had undergone LAAC. Methods From October 2019 to September 2023, patients with NVAF who underwent LAAC at our hospital were enrolled. We investigated the percentage of patients with a history of GIB who underwent LAAC and compared the incidence of post‐LAAC bleeding in these patients compared to those with other factors. Results A total of 45 patients were included. There were 19 patients (42%) with a history of GIB who underwent LAAC. In a Kaplan–Meier analysis, the cumulative incidence of bleeding complications after LAAC was significantly higher in patients with a history of GIB in comparison to patients with other factors. There were eight cases of post‐LAAC bleeding in total, and seven cases had GIB. Conclusions We need to recognize that GIB is a significant complication in patients who undergo LAAC. The management of GIB by gastroenterologists is essential to the success of LAAC.https://doi.org/10.1002/jgh3.13009antithrombotic drugsgastrointestinal bleedingleft atrial appendage closure |
| spellingShingle | Tatsuya Kikuchi Yoshiyasu Kono Koji Nakagawa Hiroyuki Okada Masakazu Miyamoto Yoichi Takaya Shoichiro Hirata Shoko Inoo Sakiko Kuraoka Shotaro Okanoue Katsunori Matsueda Takuya Satomi Kenta Hamada Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure JGH Open antithrombotic drugs gastrointestinal bleeding left atrial appendage closure |
| title | Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| title_full | Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| title_fullStr | Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| title_full_unstemmed | Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| title_short | Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| title_sort | clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure |
| topic | antithrombotic drugs gastrointestinal bleeding left atrial appendage closure |
| url | https://doi.org/10.1002/jgh3.13009 |
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