Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents
Objective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2016-09-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553616300751 |
| _version_ | 1811192972166823936 |
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| author | Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy‐Matos Mario Vaisman |
| author_facet | Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy‐Matos Mario Vaisman |
| author_sort | Luciana Lopes de Souza |
| collection | DOAJ |
| description | Objective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents.
Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was performed. The TSH and free T4 (fT4) levels, anthropometric measurements, and laboratory test results of these patients were analyzed.
Results: 27 individuals (13.56%) presented with TSH levels above the normal level (subclinical hypothyroidism [SCH]). Their waist circumference (WC) was significantly higher than those of euthyroid individuals. Serum TSH was positively correlated with the homeostasis model assessment of insulin resistance (HOMA‐IR) index, triglycerides (TG) and high‐density lipoprotein cholesterol (HDL‐C). Using TSH and BMI as independent variables, TSH levels were shown to be independently related to HOMA‐IR (p = 0.001) and TG (p = 0.007). Among euthyroid subjects, individuals with TSH values < 2.5 mIU/mL exhibited statistically significant decreases in waist‐to‐hip ratio, HDL‐C levels, and HOMA‐IR scores and a tendency towards lower WC values.
Conclusion: SCH in overweight and obese adolescents appears to be associated with excess weight, especially visceral weight. In euthyroid adolescents, there appears to be a direct relationship between TSH and some CRF. In conclusion, in the present sample of overweight and obese adolescents, TSH levels appear to be associated with IR and CRF. |
| first_indexed | 2024-04-12T00:00:51Z |
| format | Article |
| id | doaj.art-87d68bac6cbc4414b9222bb15d761398 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:00:51Z |
| publishDate | 2016-09-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-87d68bac6cbc4414b9222bb15d7613982022-12-22T03:56:14ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362016-09-0192553253810.1016/j.jpedp.2016.06.013Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescentsLuciana Lopes de Souza0Erika Paniago Guedes1Patrícia Fátima dos Santos Teixeira2Rodrigo Oliveira Moreira3Amelio Fernando Godoy‐Matos4Mario Vaisman5Instituto Estadual de Diabetes e Endocrinologia (IEDE), Divisão de Metabologia, Rio de Janeiro, RJ, BrasilInstituto Estadual de Diabetes e Endocrinologia (IEDE), Divisão de Metabologia, Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro (UFRJ), Divisão de Endocrinologia, Rio de Janeiro, RJ, BrasilInstituto Estadual de Diabetes e Endocrinologia (IEDE), Divisão de Metabologia, Rio de Janeiro, RJ, BrasilInstituto Estadual de Diabetes e Endocrinologia (IEDE), Divisão de Metabologia, Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro (UFRJ), Divisão de Endocrinologia, Rio de Janeiro, RJ, BrasilObjective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was performed. The TSH and free T4 (fT4) levels, anthropometric measurements, and laboratory test results of these patients were analyzed. Results: 27 individuals (13.56%) presented with TSH levels above the normal level (subclinical hypothyroidism [SCH]). Their waist circumference (WC) was significantly higher than those of euthyroid individuals. Serum TSH was positively correlated with the homeostasis model assessment of insulin resistance (HOMA‐IR) index, triglycerides (TG) and high‐density lipoprotein cholesterol (HDL‐C). Using TSH and BMI as independent variables, TSH levels were shown to be independently related to HOMA‐IR (p = 0.001) and TG (p = 0.007). Among euthyroid subjects, individuals with TSH values < 2.5 mIU/mL exhibited statistically significant decreases in waist‐to‐hip ratio, HDL‐C levels, and HOMA‐IR scores and a tendency towards lower WC values. Conclusion: SCH in overweight and obese adolescents appears to be associated with excess weight, especially visceral weight. In euthyroid adolescents, there appears to be a direct relationship between TSH and some CRF. In conclusion, in the present sample of overweight and obese adolescents, TSH levels appear to be associated with IR and CRF.http://www.sciencedirect.com/science/article/pii/S2255553616300751Subclinical hypothyroidismAdolescentsObesityOverweightCardiovascular risk factors |
| spellingShingle | Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy‐Matos Mario Vaisman Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents Jornal de Pediatria (Versão em Português) Subclinical hypothyroidism Adolescents Obesity Overweight Cardiovascular risk factors |
| title | Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| title_full | Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| title_fullStr | Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| title_full_unstemmed | Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| title_short | Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| title_sort | serum tsh levels are associated with cardiovascular risk factors in overweight and obese adolescents |
| topic | Subclinical hypothyroidism Adolescents Obesity Overweight Cardiovascular risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2255553616300751 |
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