The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries
Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H<sub>2</sub>Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Th...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/12/4826 |
| _version_ | 1827736184283987968 |
|---|---|
| author | Peter Balis Andrea Berenyiova Anton Misak Marian Grman Zuzana Rostakova Iveta Waczulikova Sona Cacanyiova Enrique Domínguez-Álvarez Karol Ondrias |
| author_facet | Peter Balis Andrea Berenyiova Anton Misak Marian Grman Zuzana Rostakova Iveta Waczulikova Sona Cacanyiova Enrique Domínguez-Álvarez Karol Ondrias |
| author_sort | Peter Balis |
| collection | DOAJ |
| description | Phthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H<sub>2</sub>Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg<sup>−1</sup>), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dt<sub>max</sub> relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dt<sub>min</sub> delay, dP/dt<sub>d</sub> delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L<sup>−1</sup>) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters. |
| first_indexed | 2024-03-11T02:06:24Z |
| format | Article |
| id | doaj.art-87d695db54f14a028b4411537f232a36 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:06:24Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-87d695db54f14a028b4411537f232a362023-11-18T11:50:53ZengMDPI AGMolecules1420-30492023-06-012812482610.3390/molecules28124826The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal ArteriesPeter Balis0Andrea Berenyiova1Anton Misak2Marian Grman3Zuzana Rostakova4Iveta Waczulikova5Sona Cacanyiova6Enrique Domínguez-Álvarez7Karol Ondrias8Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, SlovakiaInstitute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, SlovakiaInstitute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, SlovakiaInstitute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, SlovakiaInstitute of Measurement Science, Slovak Academy of Sciences, Dubravska Cesta 9, 841 04 Bratislava, SlovakiaFaculty of Mathematics, Physics and Informatics, Comenius University, Mlynska Dolina F1, 842 48 Bratislava, SlovakiaInstitute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, SlovakiaInstituto de Química Orgánica General (IQOG), Consejo Superior de Investigaciones Científicas CSIC, Juan de la Cierva 3, 28006 Madrid, SpainInstitute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, SlovakiaPhthalic selenoanhydride (R-Se) solved in physiological buffer releases various reactive selenium species including H<sub>2</sub>Se. It is a potential compound for Se supplementation which exerts several biological effects, but its effect on the cardiovascular system is still unknown. Therefore, herein we aimed to study how R-Se affects rat hemodynamic parameters and vasoactive properties in isolated arteries. The right jugular vein of anesthetized Wistar male rats was cannulated for IV administration of R-Se. The arterial pulse waveform (APW) was detected by cannulation of the left carotid artery, enabling the evaluation of 35 parameters. R-Se (1–2 µmol kg<sup>−1</sup>), but not phthalic anhydride or phthalic thioanhydride, transiently modulated most of the APW parameters including a decrease in systolic and diastolic blood pressure, heart rate, dP/dt<sub>max</sub> relative level, or anacrotic/dicrotic notches, whereas systolic area, dP/dt<sub>min</sub> delay, dP/dt<sub>d</sub> delay, anacrotic notch relative level or its delay increased. R-Se (~10–100 µmol L<sup>−1</sup>) significantly decreased the tension of precontracted mesenteric, femoral, and renal arteries, whereas it showed a moderate vasorelaxation effect on thoracic aorta isolated from normotensive Wistar rats. The results imply that R-Se acts on vascular smooth muscle cells, which might underlie the effects of R-Se on the rat hemodynamic parameters.https://www.mdpi.com/1420-3049/28/12/4826phthalic selenoanhydridehemodynamic parametersvasorelaxationrats |
| spellingShingle | Peter Balis Andrea Berenyiova Anton Misak Marian Grman Zuzana Rostakova Iveta Waczulikova Sona Cacanyiova Enrique Domínguez-Álvarez Karol Ondrias The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries Molecules phthalic selenoanhydride hemodynamic parameters vasorelaxation rats |
| title | The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries |
| title_full | The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries |
| title_fullStr | The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries |
| title_full_unstemmed | The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries |
| title_short | The Phthalic Selenoanhydride Decreases Rat Blood Pressure and Tension of Isolated Mesenteric, Femoral and Renal Arteries |
| title_sort | phthalic selenoanhydride decreases rat blood pressure and tension of isolated mesenteric femoral and renal arteries |
| topic | phthalic selenoanhydride hemodynamic parameters vasorelaxation rats |
| url | https://www.mdpi.com/1420-3049/28/12/4826 |
| work_keys_str_mv | AT peterbalis thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT andreaberenyiova thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT antonmisak thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT mariangrman thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT zuzanarostakova thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT ivetawaczulikova thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT sonacacanyiova thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT enriquedominguezalvarez thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT karolondrias thephthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT peterbalis phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT andreaberenyiova phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT antonmisak phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT mariangrman phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT zuzanarostakova phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT ivetawaczulikova phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT sonacacanyiova phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT enriquedominguezalvarez phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries AT karolondrias phthalicselenoanhydridedecreasesratbloodpressureandtensionofisolatedmesentericfemoralandrenalarteries |