Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124‐2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions

Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124‐2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions

Abstract The decision to treat a cervical squamous intraepithelial lesion (SIL) by loop electrosurgical excision procedure (LEEP) relies heavily on a colposcopy‐directed biopsy showing high‐grade (H)SIL. Diagnosis is often supported by p16, an immunohistochemical (IHC) biomarker of high‐risk (hr)HPV...

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Bibliographic Details
Main Authors: Annemiek Leeman, David Jenkins, Marta delPino, Jaume Ordi, Aureli Torné, John Doorbar, Chris J. L. M. Meijer, Folkert J. vanKemenade, Wim G. V. Quint
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Cancer Medicine
Subjects:
cervical cancer
hrHPV
immunohistochemistry
LEEP
methylation
Online Access:https://doi.org/10.1002/cam4.2855

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