Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma
Abstract Background The purpose of this study was to compare the performance of whole-body magnetic resonance/diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS) method, with that of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT), for...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-10-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s43055-020-00290-3 |
| _version_ | 1819046267909570560 |
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| author | Gihan Hassan Gamal |
| author_facet | Gihan Hassan Gamal |
| author_sort | Gihan Hassan Gamal |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to compare the performance of whole-body magnetic resonance/diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS) method, with that of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT), for lesion detection and initial staging of patients with lymphoma using the histopathologically diagnosis as a reference standard. Results Thirty-two patients with newly pathologically proven lymphoma were enrolled in this prospective study from May 2018 to January 2020 (27 males, 5 females). All patients underwent PET/CT followed by WB-MR/DWIBS as an attempt to compare the performance of both methods for lesion detection and initial staging in patients with lymphoma. The overall sensitivity, specificity, PPV, NPV, and accuracy of 18F-FDG-PET/CT vs WB-MR/DWIBS in correlation with reference standard data in detection of lymphoma were calculated for PET/CT 96%, 100%, 100%, 80%, and 97% while those of WB-MR/DWIBS were 93%, 76%, 96%, 61%, and 91%, respectively. Conclusion 18F-FDG PET/CT remains the standard reference of imaging in evaluation of lymphoma due to its higher sensitivity and specificity over WB-MR/DWIBS. Future studies with larger cohorts are necessary for better evaluation of the role of WB-MR/DWIBS in lymphoma patients. The current study highlights the potential complementary role of WB-MRI/DWIBS in the context of bone marrow involvement evaluation omitting unnecessary bone marrow biopsy. |
| first_indexed | 2024-12-21T10:41:46Z |
| format | Article |
| id | doaj.art-87d83236f5974f7a8fdc0726db0721b8 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-21T10:41:46Z |
| publishDate | 2020-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-87d83236f5974f7a8fdc0726db0721b82022-12-21T19:06:55ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-10-015111810.1186/s43055-020-00290-3Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphomaGihan Hassan Gamal0October 6 UniversityAbstract Background The purpose of this study was to compare the performance of whole-body magnetic resonance/diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS) method, with that of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT), for lesion detection and initial staging of patients with lymphoma using the histopathologically diagnosis as a reference standard. Results Thirty-two patients with newly pathologically proven lymphoma were enrolled in this prospective study from May 2018 to January 2020 (27 males, 5 females). All patients underwent PET/CT followed by WB-MR/DWIBS as an attempt to compare the performance of both methods for lesion detection and initial staging in patients with lymphoma. The overall sensitivity, specificity, PPV, NPV, and accuracy of 18F-FDG-PET/CT vs WB-MR/DWIBS in correlation with reference standard data in detection of lymphoma were calculated for PET/CT 96%, 100%, 100%, 80%, and 97% while those of WB-MR/DWIBS were 93%, 76%, 96%, 61%, and 91%, respectively. Conclusion 18F-FDG PET/CT remains the standard reference of imaging in evaluation of lymphoma due to its higher sensitivity and specificity over WB-MR/DWIBS. Future studies with larger cohorts are necessary for better evaluation of the role of WB-MR/DWIBS in lymphoma patients. The current study highlights the potential complementary role of WB-MRI/DWIBS in the context of bone marrow involvement evaluation omitting unnecessary bone marrow biopsy.http://link.springer.com/article/10.1186/s43055-020-00290-3LymphomaWhole-body magnetic resonance with diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS)18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) |
| spellingShingle | Gihan Hassan Gamal Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma The Egyptian Journal of Radiology and Nuclear Medicine Lymphoma Whole-body magnetic resonance with diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) |
| title | Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma |
| title_full | Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma |
| title_fullStr | Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma |
| title_full_unstemmed | Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma |
| title_short | Whole-body magnetic resonance/diffusion-weighted sequence with background signal suppression (WB-MR/DWIBS) vs. 18F-FDG PET/CT in diagnosis of lymphoma |
| title_sort | whole body magnetic resonance diffusion weighted sequence with background signal suppression wb mr dwibs vs 18f fdg pet ct in diagnosis of lymphoma |
| topic | Lymphoma Whole-body magnetic resonance with diffusion-weighted imaging with background signal suppression (WB-MR/DWIBS) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) |
| url | http://link.springer.com/article/10.1186/s43055-020-00290-3 |
| work_keys_str_mv | AT gihanhassangamal wholebodymagneticresonancediffusionweightedsequencewithbackgroundsignalsuppressionwbmrdwibsvs18ffdgpetctindiagnosisoflymphoma |