Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology
Herbal remedies are in most cases still manufactured with traditional equipment installations and processes. Innovative chemical process engineering methods such as modeling and process intensification with green technology could contribute to the economic and ecologic future of those botanicals. Th...
| Hlavní autoři: | , , , |
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| Médium: | Článek |
| Jazyk: | English |
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MDPI AG
2023-01-01
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| Edice: | Pharmaceutics |
| Témata: | |
| On-line přístup: | https://www.mdpi.com/1999-4923/15/1/188 |
| _version_ | 1827622554087456768 |
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| author | Martin Tegtmeier Larissa Knierim Axel Schmidt Jochen Strube |
| author_facet | Martin Tegtmeier Larissa Knierim Axel Schmidt Jochen Strube |
| author_sort | Martin Tegtmeier |
| collection | DOAJ |
| description | Herbal remedies are in most cases still manufactured with traditional equipment installations and processes. Innovative chemical process engineering methods such as modeling and process intensification with green technology could contribute to the economic and ecologic future of those botanicals. The integration of modern unit operations such as water-based pressurized hot water extraction and inline measurement devices for process analytical technology approaches in traditional extraction processes is exemplified. The regulatory concept is based on the quality-by-design demand for autonomous feed-based recipe operation with the aid of digital twins within advanced process control. This may include real-time release testing to the automatic cleaning of validation issues. Digitalization and Industry 4.0 methods, including machine learning and artificial intelligence, are capable of keeping natural product extraction manufacturing and can contribute significantly to the future of human health. |
| first_indexed | 2024-03-09T11:27:40Z |
| format | Article |
| id | doaj.art-87d9b069b4884d099add18f162651136 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:27:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-87d9b069b4884d099add18f1626511362023-11-30T23:58:56ZengMDPI AGPharmaceutics1999-49232023-01-0115118810.3390/pharmaceutics15010188Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical TechnologyMartin Tegtmeier0Larissa Knierim1Axel Schmidt2Jochen Strube3Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstr. 15, 38678 Clausthal-Zellerfeld, GermanyInstitute for Separation and Process Technology, Clausthal University of Technology, Leibnizstr. 15, 38678 Clausthal-Zellerfeld, GermanyInstitute for Separation and Process Technology, Clausthal University of Technology, Leibnizstr. 15, 38678 Clausthal-Zellerfeld, GermanyInstitute for Separation and Process Technology, Clausthal University of Technology, Leibnizstr. 15, 38678 Clausthal-Zellerfeld, GermanyHerbal remedies are in most cases still manufactured with traditional equipment installations and processes. Innovative chemical process engineering methods such as modeling and process intensification with green technology could contribute to the economic and ecologic future of those botanicals. The integration of modern unit operations such as water-based pressurized hot water extraction and inline measurement devices for process analytical technology approaches in traditional extraction processes is exemplified. The regulatory concept is based on the quality-by-design demand for autonomous feed-based recipe operation with the aid of digital twins within advanced process control. This may include real-time release testing to the automatic cleaning of validation issues. Digitalization and Industry 4.0 methods, including machine learning and artificial intelligence, are capable of keeping natural product extraction manufacturing and can contribute significantly to the future of human health.https://www.mdpi.com/1999-4923/15/1/188herbal remedies manufacturinggreen technologywaste valorizationdigital twinsquality by designprocess analytical technology |
| spellingShingle | Martin Tegtmeier Larissa Knierim Axel Schmidt Jochen Strube Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology Pharmaceutics herbal remedies manufacturing green technology waste valorization digital twins quality by design process analytical technology |
| title | Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology |
| title_full | Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology |
| title_fullStr | Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology |
| title_full_unstemmed | Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology |
| title_short | Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology |
| title_sort | green manufacturing for herbal remedies with advanced pharmaceutical technology |
| topic | herbal remedies manufacturing green technology waste valorization digital twins quality by design process analytical technology |
| url | https://www.mdpi.com/1999-4923/15/1/188 |
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