Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance
BackgroundRadiotherapy usually leads to a decrease in the total number of lymphocytes in patients with esophageal cancer. The factors that causing lymphopenia and the clinical significance of lymphopenia are studied in this article.Patients and methods110 patients with esophageal squamous cell carci...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1096386/full |
| _version_ | 1811158920788443136 |
|---|---|
| author | Xiufang Tian Yong Hou Jianping Guo Haiyan Wu Limin Nie Hang Wang Yan Zhang Yajuan Lv |
| author_facet | Xiufang Tian Yong Hou Jianping Guo Haiyan Wu Limin Nie Hang Wang Yan Zhang Yajuan Lv |
| author_sort | Xiufang Tian |
| collection | DOAJ |
| description | BackgroundRadiotherapy usually leads to a decrease in the total number of lymphocytes in patients with esophageal cancer. The factors that causing lymphopenia and the clinical significance of lymphopenia are studied in this article.Patients and methods110 patients with esophageal squamous cell carcinoma who had undergo intensity-modulated radiation therapy were enrolled. Statistical methods were used to analyze the correlation between lymphopenia and total survival in patients with esophageal cancer during radiotherapy, and analyze the correlations between nutritional factors and lymphopenia.ResultsThere were 11 patients with the lowest lymphocyte value with level 1-2 during radiotherapy, accounting for 10% of all the patients, and 110 patients with level 3-4, accounting for 90% of all the patient. In all the enrolled patients, the incidence of lymphocyte nadir G1, G2, G3 and G4 MinALC during radiotherapy accounted for 0.91%, 9.09%, 62.73% and 27.27%, respectively.KM survival analysis showed that the overall survival of patients in the group (MinALC ≤ 0.41×109/L) was significantly lower than that of the patients in the other group (MinALC>0.43×109/L). Nutritional indicators were positively correlated with the decline degree of lymphocytes. The minimal value of lymphocyte can predict the occurrence of grade 3-4 radiation pneumonitis.ConclusionLymphopenia induced by radiotherapy can predict survival and radiation pneumonitis. Nutritional factors such as hemoglobin and albumin were positively correlated with total lymphocytes numbers induced by radiotherapy. |
| first_indexed | 2024-04-10T05:32:29Z |
| format | Article |
| id | doaj.art-87d9f3bb59e5438f8a70701e7964db79 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T05:32:29Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-87d9f3bb59e5438f8a70701e7964db792023-03-07T06:17:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.10963861096386Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significanceXiufang Tian0Yong Hou1Jianping Guo2Haiyan Wu3Limin Nie4Hang Wang5Yan Zhang6Yajuan Lv7Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, Shandong, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, Shandong, ChinaDepartment of Oncology, Maternal and Child Health Care Hospital of Zibo, Zibo, Shandong, ChinaDepartment of Pharmacy, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Pathology, Caoxian People's Hospital, Shandong, Heze, ChinaDepartment of Graduate, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Clinical Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, Shandong, ChinaBackgroundRadiotherapy usually leads to a decrease in the total number of lymphocytes in patients with esophageal cancer. The factors that causing lymphopenia and the clinical significance of lymphopenia are studied in this article.Patients and methods110 patients with esophageal squamous cell carcinoma who had undergo intensity-modulated radiation therapy were enrolled. Statistical methods were used to analyze the correlation between lymphopenia and total survival in patients with esophageal cancer during radiotherapy, and analyze the correlations between nutritional factors and lymphopenia.ResultsThere were 11 patients with the lowest lymphocyte value with level 1-2 during radiotherapy, accounting for 10% of all the patients, and 110 patients with level 3-4, accounting for 90% of all the patient. In all the enrolled patients, the incidence of lymphocyte nadir G1, G2, G3 and G4 MinALC during radiotherapy accounted for 0.91%, 9.09%, 62.73% and 27.27%, respectively.KM survival analysis showed that the overall survival of patients in the group (MinALC ≤ 0.41×109/L) was significantly lower than that of the patients in the other group (MinALC>0.43×109/L). Nutritional indicators were positively correlated with the decline degree of lymphocytes. The minimal value of lymphocyte can predict the occurrence of grade 3-4 radiation pneumonitis.ConclusionLymphopenia induced by radiotherapy can predict survival and radiation pneumonitis. Nutritional factors such as hemoglobin and albumin were positively correlated with total lymphocytes numbers induced by radiotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2023.1096386/fullesophageal squamous cell carcinomalymphopenianutritional factorssurvivalradiotherapy |
| spellingShingle | Xiufang Tian Yong Hou Jianping Guo Haiyan Wu Limin Nie Hang Wang Yan Zhang Yajuan Lv Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance Frontiers in Oncology esophageal squamous cell carcinoma lymphopenia nutritional factors survival radiotherapy |
| title | Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| title_full | Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| title_fullStr | Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| title_full_unstemmed | Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| title_short | Effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| title_sort | effect of intensity modulated radiotherapy on lymphocytes in patients with esophageal squamous cell carcinoma and its clinical significance |
| topic | esophageal squamous cell carcinoma lymphopenia nutritional factors survival radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1096386/full |
| work_keys_str_mv | AT xiufangtian effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT yonghou effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT jianpingguo effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT haiyanwu effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT liminnie effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT hangwang effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT yanzhang effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance AT yajuanlv effectofintensitymodulatedradiotherapyonlymphocytesinpatientswithesophagealsquamouscellcarcinomaanditsclinicalsignificance |