The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck.
The genus <i>Phagnalon</i> Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well as the complex mixt...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/12/23/4007 |
| _version_ | 1827592113638866944 |
|---|---|
| author | Natale Badalamenti Michela Di Napoli Giusy Castagliuolo Mario Varcamonti Maurizio Bruno Anna Zanfardino |
| author_facet | Natale Badalamenti Michela Di Napoli Giusy Castagliuolo Mario Varcamonti Maurizio Bruno Anna Zanfardino |
| author_sort | Natale Badalamenti |
| collection | DOAJ |
| description | The genus <i>Phagnalon</i> Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well as the complex mixtures of their essential oils, from several <i>Phagnalon</i> species and ssp., have shown antibiotic, antiviral, cytotoxic, and several other biological properties. In this work, the chemical composition and the antimicrobial, cytotoxic, and antioxidant properties of the Jordan accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. essential oil (EO), an extremely rare plant that grows in ravines in the Middle East, were investigated. The EO, analyzed by GC-MS, was found to be rich in terpenoid compounds, and, in particular, in oxygenated monoterpenes, with the main compound being artemisia ketone (22.3%), followed by <i>α</i>-thujone (17.7%), and santolin alcohol (14.8%). The EO had good antimicrobial activity, especially against <i>Escherichia coli</i> Gram-negative bacterium (3 mg/mL MIC values) and was also effective in counteracting in vitro biofilm formation. Furthermore, this EO showed low cytotoxicity against immortalized human keratinocytes lines, but had good antioxidant activity on the same eukaryotic cellular models. |
| first_indexed | 2024-03-09T01:45:07Z |
| format | Article |
| id | doaj.art-87daa7846f594387a6037deb9ac459e6 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T01:45:07Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-87daa7846f594387a6037deb9ac459e62023-12-08T15:23:55ZengMDPI AGPlants2223-77472023-11-011223400710.3390/plants12234007The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck.Natale Badalamenti0Michela Di Napoli1Giusy Castagliuolo2Mario Varcamonti3Maurizio Bruno4Anna Zanfardino5Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biology, University of Naples “Federico II”, Via Cinthia 6, 80100 Naples, ItalyDepartment of Biology, University of Naples “Federico II”, Via Cinthia 6, 80100 Naples, ItalyDepartment of Biology, University of Naples “Federico II”, Via Cinthia 6, 80100 Naples, ItalyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Biology, University of Naples “Federico II”, Via Cinthia 6, 80100 Naples, ItalyThe genus <i>Phagnalon</i> Cass. (Asteraceae) is composed of widely distributed species and most of them, due to the medicinal properties they possess, are widely used in folk medicine but also as spices in the culinary field. The polar and non-polar extracts, as well as the complex mixtures of their essential oils, from several <i>Phagnalon</i> species and ssp., have shown antibiotic, antiviral, cytotoxic, and several other biological properties. In this work, the chemical composition and the antimicrobial, cytotoxic, and antioxidant properties of the Jordan accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. essential oil (EO), an extremely rare plant that grows in ravines in the Middle East, were investigated. The EO, analyzed by GC-MS, was found to be rich in terpenoid compounds, and, in particular, in oxygenated monoterpenes, with the main compound being artemisia ketone (22.3%), followed by <i>α</i>-thujone (17.7%), and santolin alcohol (14.8%). The EO had good antimicrobial activity, especially against <i>Escherichia coli</i> Gram-negative bacterium (3 mg/mL MIC values) and was also effective in counteracting in vitro biofilm formation. Furthermore, this EO showed low cytotoxicity against immortalized human keratinocytes lines, but had good antioxidant activity on the same eukaryotic cellular models.https://www.mdpi.com/2223-7747/12/23/4007<i>Phagnalon sinaicum</i> Bornm. & Kneuck.Asteraceaesantolin alcohol<i>α</i>-thujoneantimicrobialscytotoxic activity |
| spellingShingle | Natale Badalamenti Michela Di Napoli Giusy Castagliuolo Mario Varcamonti Maurizio Bruno Anna Zanfardino The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. Plants <i>Phagnalon sinaicum</i> Bornm. & Kneuck. Asteraceae santolin alcohol <i>α</i>-thujone antimicrobials cytotoxic activity |
| title | The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. |
| title_full | The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. |
| title_fullStr | The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. |
| title_full_unstemmed | The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. |
| title_short | The Biological Properties of the Essential Oil from the Jordan Accession of <i>Phagnalon sinaicum</i> Bornm. & Kneuck. |
| title_sort | biological properties of the essential oil from the jordan accession of i phagnalon sinaicum i bornm kneuck |
| topic | <i>Phagnalon sinaicum</i> Bornm. & Kneuck. Asteraceae santolin alcohol <i>α</i>-thujone antimicrobials cytotoxic activity |
| url | https://www.mdpi.com/2223-7747/12/23/4007 |
| work_keys_str_mv | AT natalebadalamenti thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT micheladinapoli thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT giusycastagliuolo thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT mariovarcamonti thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT mauriziobruno thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT annazanfardino thebiologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT natalebadalamenti biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT micheladinapoli biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT giusycastagliuolo biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT mariovarcamonti biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT mauriziobruno biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck AT annazanfardino biologicalpropertiesoftheessentialoilfromthejordanaccessionofiphagnalonsinaicumibornmkneuck |