Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-03-01
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| Series: | Mycobiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/12298093.2020.1744955 |
| _version_ | 1811292977828462592 |
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| author | Eun Jeong Won Min Young Joo Dain Lee Mi-Na Kim Yeon-Joon Park Soo Hyun Kim Myung Geun Shin Jong Hee Shin |
| author_facet | Eun Jeong Won Min Young Joo Dain Lee Mi-Na Kim Yeon-Joon Park Soo Hyun Kim Myung Geun Shin Jong Hee Shin |
| author_sort | Eun Jeong Won |
| collection | DOAJ |
| description | We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea. |
| first_indexed | 2024-04-13T04:54:27Z |
| format | Article |
| id | doaj.art-87dcd97add0149e09e4ed43a30a4b728 |
| institution | Directory Open Access Journal |
| issn | 1229-8093 2092-9323 |
| language | English |
| last_indexed | 2024-04-13T04:54:27Z |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycobiology |
| spelling | doaj.art-87dcd97add0149e09e4ed43a30a4b7282022-12-22T03:01:33ZengTaylor & Francis GroupMycobiology1229-80932092-93232020-03-0148214815210.1080/12298093.2020.17449551744955Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean MulticentersEun Jeong Won0Min Young Joo1Dain Lee2Mi-Na Kim3Yeon-Joon Park4Soo Hyun Kim5Myung Geun Shin6Jong Hee Shin7Chonnam National University Medical SchoolChonnam National University Medical SchoolChonnam National University Medical SchoolUniversity of Ulsan College of Medicine and Asan Medical CenterThe Catholic University of Korea College of MedicineChonnam National University Medical SchoolChonnam National University Medical SchoolChonnam National University Medical SchoolWe investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.http://dx.doi.org/10.1080/12298093.2020.1744955aspergillus fumigatusantifungal susceptibilitycyp51a/cyp51bmulticentre |
| spellingShingle | Eun Jeong Won Min Young Joo Dain Lee Mi-Na Kim Yeon-Joon Park Soo Hyun Kim Myung Geun Shin Jong Hee Shin Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters Mycobiology aspergillus fumigatus antifungal susceptibility cyp51a/cyp51b multicentre |
| title | Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters |
| title_full | Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters |
| title_fullStr | Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters |
| title_full_unstemmed | Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters |
| title_short | Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters |
| title_sort | antifungal susceptibility tests and the cyp51 mutant strains among clinical aspergillus fumigatus isolates from korean multicenters |
| topic | aspergillus fumigatus antifungal susceptibility cyp51a/cyp51b multicentre |
| url | http://dx.doi.org/10.1080/12298093.2020.1744955 |
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