Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis
Introduction: Acute cerebellar ataxia (ACA) is the most common form of pediatric ataxia. Changes in gut flora can modulate the nervous system, influencing brain function via the gut-brain axis (GBA). This study aimed to illustrate the relationship between intestinal microbiota and ACA.Method: A tota...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00995/full |
| _version_ | 1818993691359969280 |
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| author | Jie Yu Yuanming Fan Li Wang Yanjuan Huang Jingyi Xia Le Ding Chun-Feng Wu Xiaopeng Lu Gaoxiang Ma Samuel Kim Guo Zheng Hu Guo Gang Zhang |
| author_facet | Jie Yu Yuanming Fan Li Wang Yanjuan Huang Jingyi Xia Le Ding Chun-Feng Wu Xiaopeng Lu Gaoxiang Ma Samuel Kim Guo Zheng Hu Guo Gang Zhang |
| author_sort | Jie Yu |
| collection | DOAJ |
| description | Introduction: Acute cerebellar ataxia (ACA) is the most common form of pediatric ataxia. Changes in gut flora can modulate the nervous system, influencing brain function via the gut-brain axis (GBA). This study aimed to illustrate the relationship between intestinal microbiota and ACA.Method: A total of 30 and 12 children were randomly sampled from history of intestinal surgery (HOIS) and no intestinal surgery groups (NHOIS), respectively. In addition, 10 healthy children who sought physical examination in Children's Hospital of Nanjing Medical University were recruited as a control group. The stool samples were 16S rRNA detected.Results: We observed that many ACA children had intestinal surgery history prior to the onset of ACA. The 16S rRNA sequencing indicated that HOIS and control groups were well-distinguished by principal component analysis. The discrepancy between HOIS and NHOIS groups were also displayed by principal component analysis score plot. However, no differences were found between NHOIS and control groups. The results of student's t-test were consistent with principal component analysis. A total of nine different genera were identified between HOIS and control groups. Five genera and a phylum showed significant differences between HOIS and NHOIS groups.Conclusion: Altered genera and phyla associated with ACA were identified. Our findings provide new insight into treating and preventing ACA. |
| first_indexed | 2024-12-20T20:46:05Z |
| format | Article |
| id | doaj.art-87dcfee1597147ab97e8fcd059de9005 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T20:46:05Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-87dcfee1597147ab97e8fcd059de90052022-12-21T19:27:02ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-09-011010.3389/fneur.2019.00995485846Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain AxisJie Yu0Yuanming Fan1Li Wang2Yanjuan Huang3Jingyi Xia4Le Ding5Chun-Feng Wu6Xiaopeng Lu7Gaoxiang Ma8Samuel Kim9Guo Zheng10Hu Guo11Gang Zhang12Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaClinical Metabolomics Center, China Pharmaceutical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaClinical Metabolomics Center, China Pharmaceutical University, Nanjing, ChinaDepartment of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United StatesDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, ChinaIntroduction: Acute cerebellar ataxia (ACA) is the most common form of pediatric ataxia. Changes in gut flora can modulate the nervous system, influencing brain function via the gut-brain axis (GBA). This study aimed to illustrate the relationship between intestinal microbiota and ACA.Method: A total of 30 and 12 children were randomly sampled from history of intestinal surgery (HOIS) and no intestinal surgery groups (NHOIS), respectively. In addition, 10 healthy children who sought physical examination in Children's Hospital of Nanjing Medical University were recruited as a control group. The stool samples were 16S rRNA detected.Results: We observed that many ACA children had intestinal surgery history prior to the onset of ACA. The 16S rRNA sequencing indicated that HOIS and control groups were well-distinguished by principal component analysis. The discrepancy between HOIS and NHOIS groups were also displayed by principal component analysis score plot. However, no differences were found between NHOIS and control groups. The results of student's t-test were consistent with principal component analysis. A total of nine different genera were identified between HOIS and control groups. Five genera and a phylum showed significant differences between HOIS and NHOIS groups.Conclusion: Altered genera and phyla associated with ACA were identified. Our findings provide new insight into treating and preventing ACA.https://www.frontiersin.org/article/10.3389/fneur.2019.00995/fullintestinal surgery contributesacute cerebellar ataxiagut brain axisgut flora16S rRNA |
| spellingShingle | Jie Yu Yuanming Fan Li Wang Yanjuan Huang Jingyi Xia Le Ding Chun-Feng Wu Xiaopeng Lu Gaoxiang Ma Samuel Kim Guo Zheng Hu Guo Gang Zhang Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis Frontiers in Neurology intestinal surgery contributes acute cerebellar ataxia gut brain axis gut flora 16S rRNA |
| title | Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis |
| title_full | Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis |
| title_fullStr | Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis |
| title_full_unstemmed | Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis |
| title_short | Intestinal Surgery Contributes to Acute Cerebellar Ataxia Through Gut Brain Axis |
| title_sort | intestinal surgery contributes to acute cerebellar ataxia through gut brain axis |
| topic | intestinal surgery contributes acute cerebellar ataxia gut brain axis gut flora 16S rRNA |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00995/full |
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