Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia
Hyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been considered as a high-risk factor and key indicator of many metabolic diseases. The gut microbiota has been reported playing a vital role in regulating host lipid metabolism. The pathogenic role of gut microbiota i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.634780/full |
| _version_ | 1818620689302683648 |
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| author | Xiaokang Jia Xiaokang Jia Xiaokang Jia Wen Xu Wen Xu Lei Zhang Xiaoyan Li Xiaoyan Li Ruirui Wang Shuisheng Wu Shuisheng Wu |
| author_facet | Xiaokang Jia Xiaokang Jia Xiaokang Jia Wen Xu Wen Xu Lei Zhang Xiaoyan Li Xiaoyan Li Ruirui Wang Shuisheng Wu Shuisheng Wu |
| author_sort | Xiaokang Jia |
| collection | DOAJ |
| description | Hyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been considered as a high-risk factor and key indicator of many metabolic diseases. The gut microbiota has been reported playing a vital role in regulating host lipid metabolism. The pathogenic role of gut microbiota in the development of hyperlipidemia has been revealed through fecal microbiota transplantation experiment to germ-free mice. The effector mechanism of microbiota-related metabolites such as bile acids, lipopolysaccharide, and short-chain fatty acids in the regulation of hyperlipidemia has been partially unveiled. Moreover, studies on gut-microbiota-targeted hyperlipidemia interventions, including the use of prebiotics, probiotics, fecal microbiota transplantation, and natural herbal medicines, also have shown their efficacy in the treatment of hyperlipidemia. In this review, we summarize the relationship between gut microbiota and hyperlipidemia, the impact of gut microbiota and microbiota-related metabolites on the development and progression of hyperlipidemia, and the potential therapeutic management of hyperlipidemia targeted at gut microbiota. |
| first_indexed | 2024-12-16T17:57:22Z |
| format | Article |
| id | doaj.art-87de2876773e411baf86cb8d313d8007 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-16T17:57:22Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-87de2876773e411baf86cb8d313d80072022-12-21T22:22:08ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-08-011110.3389/fcimb.2021.634780634780Impact of Gut Microbiota and Microbiota-Related Metabolites on HyperlipidemiaXiaokang Jia0Xiaokang Jia1Xiaokang Jia2Wen Xu3Wen Xu4Lei Zhang5Xiaoyan Li6Xiaoyan Li7Ruirui Wang8Shuisheng Wu9Shuisheng Wu10College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCentre of Biomedical Research & Development, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaThe Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCentre of Biomedical Research & Development, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCentre of Biomedical Research & Development, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCentre of Biomedical Research & Development, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaHyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been considered as a high-risk factor and key indicator of many metabolic diseases. The gut microbiota has been reported playing a vital role in regulating host lipid metabolism. The pathogenic role of gut microbiota in the development of hyperlipidemia has been revealed through fecal microbiota transplantation experiment to germ-free mice. The effector mechanism of microbiota-related metabolites such as bile acids, lipopolysaccharide, and short-chain fatty acids in the regulation of hyperlipidemia has been partially unveiled. Moreover, studies on gut-microbiota-targeted hyperlipidemia interventions, including the use of prebiotics, probiotics, fecal microbiota transplantation, and natural herbal medicines, also have shown their efficacy in the treatment of hyperlipidemia. In this review, we summarize the relationship between gut microbiota and hyperlipidemia, the impact of gut microbiota and microbiota-related metabolites on the development and progression of hyperlipidemia, and the potential therapeutic management of hyperlipidemia targeted at gut microbiota.https://www.frontiersin.org/articles/10.3389/fcimb.2021.634780/fullgut microbiotahyperlipidemiaBAsLPSSCFAs |
| spellingShingle | Xiaokang Jia Xiaokang Jia Xiaokang Jia Wen Xu Wen Xu Lei Zhang Xiaoyan Li Xiaoyan Li Ruirui Wang Shuisheng Wu Shuisheng Wu Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia Frontiers in Cellular and Infection Microbiology gut microbiota hyperlipidemia BAs LPS SCFAs |
| title | Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia |
| title_full | Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia |
| title_fullStr | Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia |
| title_full_unstemmed | Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia |
| title_short | Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia |
| title_sort | impact of gut microbiota and microbiota related metabolites on hyperlipidemia |
| topic | gut microbiota hyperlipidemia BAs LPS SCFAs |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.634780/full |
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