A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients

A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients

Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evidence approach for assessing oral toxicity was cha...

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Bibliographic Details
Main Authors: Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Toxicology
Subjects:
Acute oral toxicity
3T3-NRU cytotoxicity assay
Non-animal
NICEATM
EURL ECVAM
OECD
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X22000378

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