Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study
Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the ana...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000487 |
| _version_ | 1797869763883433984 |
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| author | Yajuan Zhang Chu-Chung Huang Jiajia Zhao Yuchen Liu Mingrui Xia Xiaoqin Wang Dongtao Wei Yuan Chen Bangshan Liu Yanting Zheng Yankun Wu Taolin Chen Yuqi Cheng Xiufeng Xu Qiyong Gong Tianmei Si Shijun Qiu Jingliang Cheng Yanqing Tang Fei Wang Jiang Qiu Peng Xie Lingjiang Li Yong He Ching-Po Lin Chun-Yi Zac Lo |
| author_facet | Yajuan Zhang Chu-Chung Huang Jiajia Zhao Yuchen Liu Mingrui Xia Xiaoqin Wang Dongtao Wei Yuan Chen Bangshan Liu Yanting Zheng Yankun Wu Taolin Chen Yuqi Cheng Xiufeng Xu Qiyong Gong Tianmei Si Shijun Qiu Jingliang Cheng Yanqing Tang Fei Wang Jiang Qiu Peng Xie Lingjiang Li Yong He Ching-Po Lin Chun-Yi Zac Lo |
| author_sort | Yajuan Zhang |
| collection | DOAJ |
| description | Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the analysis of connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers are involved in the pathogenesis of MDD. Here, we analyzed the resting-state functional magnetic resonance imaging (RS-fMRI) dataset from 1,148 MDD patients and 1,079 healthy individuals recruited across nine centers. A seed-based analysis with the dorsal raphe and median raphe nuclei was performed to explore the functional connectivity (FC) alterations. Compared to controls, for dorsal raphe, the significantly decreased FC linking with the right precuneus and median cingulate cortex were found; for median raphe, the increased FC linking with right superior cerebellum (lobules V/VI) was found in MDD patients. In further exploratory analyzes, MDD-related connectivity alterations in dorsal and median raphe nuclei in different clinical factors remained highly similar to the main findings, indicating these abnormal connectivities are a disease-related alteration. Our study highlights a functional dysconnection pattern of raphe nuclei in MDD with multi-site big data. These findings help improve our understanding of the pathophysiology of depression and provide evidence of the theoretical foundation for the development of novel pharmacotherapies. |
| first_indexed | 2024-04-10T00:17:24Z |
| format | Article |
| id | doaj.art-87df7d4ab0764901801255f52bc248f1 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-10T00:17:24Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-87df7d4ab0764901801255f52bc248f12023-03-16T05:04:14ZengElsevierNeuroImage: Clinical2213-15822023-01-0137103359Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site studyYajuan Zhang0Chu-Chung Huang1Jiajia Zhao2Yuchen Liu3Mingrui Xia4Xiaoqin Wang5Dongtao Wei6Yuan Chen7Bangshan Liu8Yanting Zheng9Yankun Wu10Taolin Chen11Yuqi Cheng12Xiufeng Xu13Qiyong Gong14Tianmei Si15Shijun Qiu16Jingliang Cheng17Yanqing Tang18Fei Wang19Jiang Qiu20Peng Xie21Lingjiang Li22Yong He23Ching-Po Lin24Chun-Yi Zac Lo25Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; School of Biomedical Engineering, ShanghaiTech University, Shanghai, ChinaShanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Shanghai Changning Mental Health Center, Shanghai, China; Corresponding authors.Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, ChinaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, ChinaKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, ChinaKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, Hunan, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, ChinaKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China; Department of Psychology, Southwest University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Mental Health Institute of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Hunan Medical Center for Mental Health, Changsha, Hunan, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Institute for Brain Research, Beijing, ChinaInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, 11221, TaiwanDepartment of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, 32023, Taiwan; Corresponding authors.Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the analysis of connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers are involved in the pathogenesis of MDD. Here, we analyzed the resting-state functional magnetic resonance imaging (RS-fMRI) dataset from 1,148 MDD patients and 1,079 healthy individuals recruited across nine centers. A seed-based analysis with the dorsal raphe and median raphe nuclei was performed to explore the functional connectivity (FC) alterations. Compared to controls, for dorsal raphe, the significantly decreased FC linking with the right precuneus and median cingulate cortex were found; for median raphe, the increased FC linking with right superior cerebellum (lobules V/VI) was found in MDD patients. In further exploratory analyzes, MDD-related connectivity alterations in dorsal and median raphe nuclei in different clinical factors remained highly similar to the main findings, indicating these abnormal connectivities are a disease-related alteration. Our study highlights a functional dysconnection pattern of raphe nuclei in MDD with multi-site big data. These findings help improve our understanding of the pathophysiology of depression and provide evidence of the theoretical foundation for the development of novel pharmacotherapies.http://www.sciencedirect.com/science/article/pii/S2213158223000487SerotoninDorsal and median raphe nucleiSeed-based analysisResting-state fMRI dataFunctional connectivityMulticenter |
| spellingShingle | Yajuan Zhang Chu-Chung Huang Jiajia Zhao Yuchen Liu Mingrui Xia Xiaoqin Wang Dongtao Wei Yuan Chen Bangshan Liu Yanting Zheng Yankun Wu Taolin Chen Yuqi Cheng Xiufeng Xu Qiyong Gong Tianmei Si Shijun Qiu Jingliang Cheng Yanqing Tang Fei Wang Jiang Qiu Peng Xie Lingjiang Li Yong He Ching-Po Lin Chun-Yi Zac Lo Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study NeuroImage: Clinical Serotonin Dorsal and median raphe nuclei Seed-based analysis Resting-state fMRI data Functional connectivity Multicenter |
| title | Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study |
| title_full | Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study |
| title_fullStr | Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study |
| title_full_unstemmed | Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study |
| title_short | Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study |
| title_sort | resting state functional connectivity of the raphe nuclei in major depressive disorder a multi site study |
| topic | Serotonin Dorsal and median raphe nuclei Seed-based analysis Resting-state fMRI data Functional connectivity Multicenter |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000487 |
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