Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis
Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to 1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium tuberculosis (Mtb), which primarily infects innate immune cells in the lungs. These immune cells play a critical role in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260859/full |
| _version_ | 1797647966493736960 |
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| author | Poornima Sankar Bibhuti Bhusan Mishra |
| author_facet | Poornima Sankar Bibhuti Bhusan Mishra |
| author_sort | Poornima Sankar |
| collection | DOAJ |
| description | Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to 1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium tuberculosis (Mtb), which primarily infects innate immune cells in the lungs. These immune cells play a critical role in the host defense against Mtb infection, influencing the inflammatory environment in the lungs, and facilitating the development of adaptive immunity. However, Mtb exploits and manipulates innate immune cells, using them as favorable niche for replication. Unfortunately, our understanding of the early interactions between Mtb and innate effector cells remains limited. This review underscores the interactions between Mtb and various innate immune cells, such as macrophages, dendritic cells, granulocytes, NK cells, innate lymphocytes-iNKT and ILCs. In addition, the contribution of alveolar epithelial cell and endothelial cells that constitutes the mucosal barrier in TB immunity will be discussed. Gaining insights into the early cellular basis of immune reactions to Mtb infection is crucial for our understanding of Mtb resistance and disease tolerance mechanisms. We argue that a better understanding of the early host-pathogen interactions could inform on future vaccination approaches and devise intervention strategies. |
| first_indexed | 2024-03-11T15:25:17Z |
| format | Article |
| id | doaj.art-87e132c0698a45beb79fcced2912da72 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T15:25:17Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-87e132c0698a45beb79fcced2912da722023-10-27T22:01:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-10-011410.3389/fimmu.2023.12608591260859Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosisPoornima SankarBibhuti Bhusan MishraTuberculosis (TB) remains a significant global health challenge, claiming the lives of up to 1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium tuberculosis (Mtb), which primarily infects innate immune cells in the lungs. These immune cells play a critical role in the host defense against Mtb infection, influencing the inflammatory environment in the lungs, and facilitating the development of adaptive immunity. However, Mtb exploits and manipulates innate immune cells, using them as favorable niche for replication. Unfortunately, our understanding of the early interactions between Mtb and innate effector cells remains limited. This review underscores the interactions between Mtb and various innate immune cells, such as macrophages, dendritic cells, granulocytes, NK cells, innate lymphocytes-iNKT and ILCs. In addition, the contribution of alveolar epithelial cell and endothelial cells that constitutes the mucosal barrier in TB immunity will be discussed. Gaining insights into the early cellular basis of immune reactions to Mtb infection is crucial for our understanding of Mtb resistance and disease tolerance mechanisms. We argue that a better understanding of the early host-pathogen interactions could inform on future vaccination approaches and devise intervention strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260859/fullMycobacterium tuberculosishost-pathogen interactionsalveolar epithelial cellsgranulocytesinflammationinnate immunity |
| spellingShingle | Poornima Sankar Bibhuti Bhusan Mishra Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis Frontiers in Immunology Mycobacterium tuberculosis host-pathogen interactions alveolar epithelial cells granulocytes inflammation innate immunity |
| title | Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis |
| title_full | Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis |
| title_fullStr | Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis |
| title_full_unstemmed | Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis |
| title_short | Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis |
| title_sort | early innate cell interactions with mycobacterium tuberculosis in protection and pathology of tuberculosis |
| topic | Mycobacterium tuberculosis host-pathogen interactions alveolar epithelial cells granulocytes inflammation innate immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260859/full |
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