Paradoxical Roles of Desmosomal Components in Head and Neck Cancer
Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progressio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/6/914 |
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| author | Yin-Qiao Liu Hai-Ying Zou Jian-Jun Xie Wang-Kai Fang |
| author_facet | Yin-Qiao Liu Hai-Ying Zou Jian-Jun Xie Wang-Kai Fang |
| author_sort | Yin-Qiao Liu |
| collection | DOAJ |
| description | Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progression and poor survival. In addition, desmosomes have been shown to act as a signaling platform to regulate the proliferation, invasion, migration, morphogenesis, and apoptosis of cancer cells. The occurrence and progression of head and neck cancer (HNC) is accompanied by abnormal expression of desmosomal components and loss of desmosome structure. However, the role of desmosomal components in the progression of HNC remains controversial. This review aims to provide an overview of recent developments showing the paradoxical roles of desmosomal components in tumor suppression and promotion. It offers valuable insights for HNC diagnosis and therapeutics development. |
| first_indexed | 2024-03-10T10:14:47Z |
| format | Article |
| id | doaj.art-87e18becc19747e78250a413d58bb32b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T10:14:47Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-87e18becc19747e78250a413d58bb32b2023-11-22T00:56:41ZengMDPI AGBiomolecules2218-273X2021-06-0111691410.3390/biom11060914Paradoxical Roles of Desmosomal Components in Head and Neck CancerYin-Qiao Liu0Hai-Ying Zou1Jian-Jun Xie2Wang-Kai Fang3Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDesmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progression and poor survival. In addition, desmosomes have been shown to act as a signaling platform to regulate the proliferation, invasion, migration, morphogenesis, and apoptosis of cancer cells. The occurrence and progression of head and neck cancer (HNC) is accompanied by abnormal expression of desmosomal components and loss of desmosome structure. However, the role of desmosomal components in the progression of HNC remains controversial. This review aims to provide an overview of recent developments showing the paradoxical roles of desmosomal components in tumor suppression and promotion. It offers valuable insights for HNC diagnosis and therapeutics development.https://www.mdpi.com/2218-273X/11/6/914desmosomeshead and neck cancerdesmosomal cadherinsarmadillo proteinsplakin proteins |
| spellingShingle | Yin-Qiao Liu Hai-Ying Zou Jian-Jun Xie Wang-Kai Fang Paradoxical Roles of Desmosomal Components in Head and Neck Cancer Biomolecules desmosomes head and neck cancer desmosomal cadherins armadillo proteins plakin proteins |
| title | Paradoxical Roles of Desmosomal Components in Head and Neck Cancer |
| title_full | Paradoxical Roles of Desmosomal Components in Head and Neck Cancer |
| title_fullStr | Paradoxical Roles of Desmosomal Components in Head and Neck Cancer |
| title_full_unstemmed | Paradoxical Roles of Desmosomal Components in Head and Neck Cancer |
| title_short | Paradoxical Roles of Desmosomal Components in Head and Neck Cancer |
| title_sort | paradoxical roles of desmosomal components in head and neck cancer |
| topic | desmosomes head and neck cancer desmosomal cadherins armadillo proteins plakin proteins |
| url | https://www.mdpi.com/2218-273X/11/6/914 |
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