Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout (Ces1–/–) mice, and a hepatic human CES1 transgeni...

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Bibliographic Details
Main Authors: Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ces1/CES1 enzymes
Irinotecan
Capecitabine
Adipose tissue
Lipid homeostasis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522004415

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