Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats
Abstract Previous studies have shown that single-frequency microwave radiation can lead to cognitive decline in rats. However, few studies have focused on the combined effects of irradiation with different frequencies of microwaves. Our research aimed to investigate the effects of 1.5 GHz and 4.3 GH...
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-89348-4 |
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| author | Ruiqing Zhu Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Hongmei Zhou Yabing Gao Ruiyun Peng |
| author_facet | Ruiqing Zhu Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Hongmei Zhou Yabing Gao Ruiyun Peng |
| author_sort | Ruiqing Zhu |
| collection | DOAJ |
| description | Abstract Previous studies have shown that single-frequency microwave radiation can lead to cognitive decline in rats. However, few studies have focused on the combined effects of irradiation with different frequencies of microwaves. Our research aimed to investigate the effects of 1.5 GHz and 4.3 GHz microwave radiation, singly and in combination, on cognitive function and hippocampal tissue structure in rats. A total of 140 male Wistar rats were randomly divided into 4 groups: the S group (sham radiation group), L10 group (10 mW/cm2 1.5 GHz group), C10 group (10 mW/cm2 4.3 GHz band group) and LC10 group (10 mW/cm2 1.5 and 4.3 GHz multi-frequency radiation group). For 1–28 days after microwave radiation, we analyzed the average escape latency for the Morris water maze task, electroencephalograms, change in hippocampal tissue structure and ultrastructure, content of the Nissl body in the hippocampus, and activities of lactate dehydrogenase and succinate dehydrogenase. Compared to the S group, all exposure groups showed varying degrees of learning and memory decline and hippocampal structural damage. The results showed that 1.5 GHz and 4.3 GHz microwave radiation was able to induce cognitive impairment and hippocampal tissue damage in rats and combined radiation with both frequencies caused more serious injuries, but none of these damaging effects varied with microwave frequency. |
| first_indexed | 2024-12-19T03:50:49Z |
| format | Article |
| id | doaj.art-87e26c7f5cb243608b3bf2a7ecb7f61d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T03:50:49Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-87e26c7f5cb243608b3bf2a7ecb7f61d2022-12-21T20:37:00ZengNature PortfolioScientific Reports2045-23222021-05-0111111210.1038/s41598-021-89348-4Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar ratsRuiqing Zhu0Hui Wang1Xinping Xu2Li Zhao3Jing Zhang4Ji Dong5Binwei Yao6Haoyu Wang7Hongmei Zhou8Yabing Gao9Ruiyun Peng10Department of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineDepartment of Experimental Pathology, Beijing Institute of Radiation MedicineAbstract Previous studies have shown that single-frequency microwave radiation can lead to cognitive decline in rats. However, few studies have focused on the combined effects of irradiation with different frequencies of microwaves. Our research aimed to investigate the effects of 1.5 GHz and 4.3 GHz microwave radiation, singly and in combination, on cognitive function and hippocampal tissue structure in rats. A total of 140 male Wistar rats were randomly divided into 4 groups: the S group (sham radiation group), L10 group (10 mW/cm2 1.5 GHz group), C10 group (10 mW/cm2 4.3 GHz band group) and LC10 group (10 mW/cm2 1.5 and 4.3 GHz multi-frequency radiation group). For 1–28 days after microwave radiation, we analyzed the average escape latency for the Morris water maze task, electroencephalograms, change in hippocampal tissue structure and ultrastructure, content of the Nissl body in the hippocampus, and activities of lactate dehydrogenase and succinate dehydrogenase. Compared to the S group, all exposure groups showed varying degrees of learning and memory decline and hippocampal structural damage. The results showed that 1.5 GHz and 4.3 GHz microwave radiation was able to induce cognitive impairment and hippocampal tissue damage in rats and combined radiation with both frequencies caused more serious injuries, but none of these damaging effects varied with microwave frequency.https://doi.org/10.1038/s41598-021-89348-4 |
| spellingShingle | Ruiqing Zhu Hui Wang Xinping Xu Li Zhao Jing Zhang Ji Dong Binwei Yao Haoyu Wang Hongmei Zhou Yabing Gao Ruiyun Peng Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats Scientific Reports |
| title | Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats |
| title_full | Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats |
| title_fullStr | Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats |
| title_full_unstemmed | Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats |
| title_short | Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats |
| title_sort | effects of 1 5 and 4 3 ghz microwave radiation on cognitive function and hippocampal tissue structure in wistar rats |
| url | https://doi.org/10.1038/s41598-021-89348-4 |
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