KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities

KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities

KDEL receptors (KDELRs) are ubiquitous seven-transmembrane domain proteins encoded by three mammalian genes. They bind to and retro-transport endoplasmic reticulum (ER)-resident proteins with a C-terminal Lys-Asp-Glu-Leu (KDEL) sequence or variants thereof. In doing this, KDELR participates in the E...

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Bibliographic Details
Main Authors: Ilaria Cela, Beatrice Dufrusine, Claudia Rossi, Alberto Luini, Vincenzo De Laurenzi, Luca Federici, Michele Sallese
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
endoplasmic reticulum homeostasis
chaperones retrieval
unfolded protein response
viruses trafficking
targeted therapies
Online Access:https://www.mdpi.com/2227-9059/10/6/1234

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https://www.mdpi.com/2227-9059/10/6/1234

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