Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination
We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to ster...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00600/full |
| _version_ | 1818057651134660608 |
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| author | Masaya Harada Shiroh Miura Hiroshi Kida Taiga Moritaka Ken-ichi Irie Takashi Kamada Yusuke Uchiyama Sayuri Shima Tatsuro Mutoh Tomoaki Hoshino Takayuki Taniwaki |
| author_facet | Masaya Harada Shiroh Miura Hiroshi Kida Taiga Moritaka Ken-ichi Irie Takashi Kamada Yusuke Uchiyama Sayuri Shima Tatsuro Mutoh Tomoaki Hoshino Takayuki Taniwaki |
| author_sort | Masaya Harada |
| collection | DOAJ |
| description | We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy. |
| first_indexed | 2024-12-10T12:48:07Z |
| format | Article |
| id | doaj.art-87e40bb1ce0e420a9ab7cc7d060cc615 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T12:48:07Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-87e40bb1ce0e420a9ab7cc7d060cc6152022-12-22T01:48:21ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-06-011010.3389/fneur.2019.00600457804Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral DemyelinationMasaya Harada0Shiroh Miura1Hiroshi Kida2Taiga Moritaka3Ken-ichi Irie4Takashi Kamada5Yusuke Uchiyama6Sayuri Shima7Tatsuro Mutoh8Tomoaki Hoshino9Takayuki Taniwaki10Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDepartment of Radiology, Kurume University School of Medicine, Kurume, JapanDepartment of Neurology, Fujita Health University School of Medicine, Aichi, JapanDepartment of Neurology, Fujita Health University School of Medicine, Aichi, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanDivision of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, JapanWe describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.https://www.frontiersin.org/article/10.3389/fneur.2019.00600/fullcombined central and peripheral demyelination (CCPD)encephalomyeloradiculoneuropathy (EMRN)lactosylceramidereversible conduction failure (RCF)total plasma exchangesteroid |
| spellingShingle | Masaya Harada Shiroh Miura Hiroshi Kida Taiga Moritaka Ken-ichi Irie Takashi Kamada Yusuke Uchiyama Sayuri Shima Tatsuro Mutoh Tomoaki Hoshino Takayuki Taniwaki Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination Frontiers in Neurology combined central and peripheral demyelination (CCPD) encephalomyeloradiculoneuropathy (EMRN) lactosylceramide reversible conduction failure (RCF) total plasma exchange steroid |
| title | Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination |
| title_full | Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination |
| title_fullStr | Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination |
| title_full_unstemmed | Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination |
| title_short | Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination |
| title_sort | reversible conduction failure in anti lactosylceramide antibody positive combined central and peripheral demyelination |
| topic | combined central and peripheral demyelination (CCPD) encephalomyeloradiculoneuropathy (EMRN) lactosylceramide reversible conduction failure (RCF) total plasma exchange steroid |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00600/full |
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