Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
Bacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18236-8 |
| _version_ | 1818430330395164672 |
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| author | Christopher M. Bellas Declan C. Schroeder Arwyn Edwards Gary Barker Alexandre M. Anesio |
| author_facet | Christopher M. Bellas Declan C. Schroeder Arwyn Edwards Gary Barker Alexandre M. Anesio |
| author_sort | Christopher M. Bellas |
| collection | DOAJ |
| description | Bacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-identical core genomes maintain diversity by possession of numerous flexible gene modules, where homologous genes present in the pan-genome interchange to create new phage variants. |
| first_indexed | 2024-12-14T15:31:42Z |
| format | Article |
| id | doaj.art-87e483e9dc33413790e4656412d76b4c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:31:42Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-87e483e9dc33413790e4656412d76b4c2022-12-21T22:55:52ZengNature PortfolioNature Communications2041-17232020-09-0111111010.1038/s41467-020-18236-8Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystemsChristopher M. Bellas0Declan C. Schroeder1Arwyn Edwards2Gary Barker3Alexandre M. Anesio4Department of Ecology, Lake and Glacier Ecology, University of InnsbruckDepartment of Veterinary Population Medicine, University of MinnesotaInstitute of Biological, Environmental and Rural Sciences, Aberystwyth UniversitySchool of Biological Sciences, University of BristolDepartment of Environmental Science, Aarhus UniversityBacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-identical core genomes maintain diversity by possession of numerous flexible gene modules, where homologous genes present in the pan-genome interchange to create new phage variants.https://doi.org/10.1038/s41467-020-18236-8 |
| spellingShingle | Christopher M. Bellas Declan C. Schroeder Arwyn Edwards Gary Barker Alexandre M. Anesio Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems Nature Communications |
| title | Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems |
| title_full | Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems |
| title_fullStr | Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems |
| title_full_unstemmed | Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems |
| title_short | Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems |
| title_sort | flexible genes establish widespread bacteriophage pan genomes in cryoconite hole ecosystems |
| url | https://doi.org/10.1038/s41467-020-18236-8 |
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