Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland
Abstract Background We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. isolated from 2005 to 2016 in different regions of Switzerland. Methods Using the Swiss Antibiotic Resistance Centre (anresis) database that includes data from 70% of all hospitalized patients and one...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3061-5 |
| _version_ | 1818301671203143680 |
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| author | A. Ramette A. Kronenberg and the Swiss Centre for Antibiotic Resistance (ANRESIS) |
| author_facet | A. Ramette A. Kronenberg and the Swiss Centre for Antibiotic Resistance (ANRESIS) |
| author_sort | A. Ramette |
| collection | DOAJ |
| description | Abstract Background We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. isolated from 2005 to 2016 in different regions of Switzerland. Methods Using the Swiss Antibiotic Resistance Centre (anresis) database that includes data from 70% of all hospitalized patients and one third of all ambulatory practitioners in Switzerland, we analysed the number of carbapenem-susceptible and resistant Acinetobacter spp. isolated from blood or cerebrospinal fluid, and further described their temporal and regional fluctuations. Results From 2005 to 2016, 58 cases of resistant or intermediate strains to carbapenem were observed among 632 cases of invasive Acinetobacter. Multivariable analyses indicated that the number of carbapenem-resistant isolates (mean 4.8 ± sd 2.12) and carbapenem resistance rates per region per annum (8.4% ± 13.9%) were low and stable over the studied period. Large fluctuations were observed at the regional level, with e.g. the North East region displaying resistance rates twice as high as that found in other regions. Conclusion Despite a relatively stable number of carbapenem-resistant Acinetobacter isolates in Switzerland, our results suggest the existence of a diverse pool of A. baumannii species in hospital settings, and confirm the implication of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex in the vast majority of clinical infections and nosocomial outbreaks with notable regional fluctuations. |
| first_indexed | 2024-12-13T05:26:43Z |
| format | Article |
| id | doaj.art-87e546d29a604e12a4181431be07e64b |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T05:26:43Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-87e546d29a604e12a4181431be07e64b2022-12-21T23:58:10ZengBMCBMC Infectious Diseases1471-23342018-04-011811610.1186/s12879-018-3061-5Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in SwitzerlandA. Ramette0A. Kronenberg1and the Swiss Centre for Antibiotic Resistance (ANRESIS)Institute for Infectious Diseases, University of BernInstitute for Infectious Diseases, University of BernAbstract Background We describe the prevalence of invasive carbapenem-resistant Acinetobacter spp. isolated from 2005 to 2016 in different regions of Switzerland. Methods Using the Swiss Antibiotic Resistance Centre (anresis) database that includes data from 70% of all hospitalized patients and one third of all ambulatory practitioners in Switzerland, we analysed the number of carbapenem-susceptible and resistant Acinetobacter spp. isolated from blood or cerebrospinal fluid, and further described their temporal and regional fluctuations. Results From 2005 to 2016, 58 cases of resistant or intermediate strains to carbapenem were observed among 632 cases of invasive Acinetobacter. Multivariable analyses indicated that the number of carbapenem-resistant isolates (mean 4.8 ± sd 2.12) and carbapenem resistance rates per region per annum (8.4% ± 13.9%) were low and stable over the studied period. Large fluctuations were observed at the regional level, with e.g. the North East region displaying resistance rates twice as high as that found in other regions. Conclusion Despite a relatively stable number of carbapenem-resistant Acinetobacter isolates in Switzerland, our results suggest the existence of a diverse pool of A. baumannii species in hospital settings, and confirm the implication of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex in the vast majority of clinical infections and nosocomial outbreaks with notable regional fluctuations.http://link.springer.com/article/10.1186/s12879-018-3061-5Carbapenem resistanceAcinetobacter baumannii complexSurveillanceEpidemiologyTemporal trendsRegional trends |
| spellingShingle | A. Ramette A. Kronenberg and the Swiss Centre for Antibiotic Resistance (ANRESIS) Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland BMC Infectious Diseases Carbapenem resistance Acinetobacter baumannii complex Surveillance Epidemiology Temporal trends Regional trends |
| title | Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland |
| title_full | Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland |
| title_fullStr | Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland |
| title_full_unstemmed | Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland |
| title_short | Prevalence of carbapenem-resistant Acinetobacter baumannii from 2005 to 2016 in Switzerland |
| title_sort | prevalence of carbapenem resistant acinetobacter baumannii from 2005 to 2016 in switzerland |
| topic | Carbapenem resistance Acinetobacter baumannii complex Surveillance Epidemiology Temporal trends Regional trends |
| url | http://link.springer.com/article/10.1186/s12879-018-3061-5 |
| work_keys_str_mv | AT aramette prevalenceofcarbapenemresistantacinetobacterbaumanniifrom2005to2016inswitzerland AT akronenberg prevalenceofcarbapenemresistantacinetobacterbaumanniifrom2005to2016inswitzerland AT andtheswisscentreforantibioticresistanceanresis prevalenceofcarbapenemresistantacinetobacterbaumanniifrom2005to2016inswitzerland |