Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound
To date, studies which utilized ultrasound (US) and optoacoustic tomography (OT) fusion (US-OT) in biochemical differentiation of malignant and benign breast conditions have relied on limited biochemical data such as oxyhaemoglobin (OH) and deoxyhaemoglobin (DH) only. There has been no data of the l...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597922000428 |
| _version_ | 1818516370065719296 |
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| author | Yonggeng Goh Ghayathri Balasundaram Hui Min Tan Thomas Choudary Putti Siau Wei Tang Celene Wei Qi Ng Shaik Ahmad Buhari Eric Fang Mohesh Moothanchery Renzhe Bi Malini Olivo Swee Tian Quek |
| author_facet | Yonggeng Goh Ghayathri Balasundaram Hui Min Tan Thomas Choudary Putti Siau Wei Tang Celene Wei Qi Ng Shaik Ahmad Buhari Eric Fang Mohesh Moothanchery Renzhe Bi Malini Olivo Swee Tian Quek |
| author_sort | Yonggeng Goh |
| collection | DOAJ |
| description | To date, studies which utilized ultrasound (US) and optoacoustic tomography (OT) fusion (US-OT) in biochemical differentiation of malignant and benign breast conditions have relied on limited biochemical data such as oxyhaemoglobin (OH) and deoxyhaemoglobin (DH) only. There has been no data of the largest biochemical components of breast fibroglandular tissue: lipid and collagen. Here, the authors believe the ability to image collagen and lipids within the breast tissue could serve as an important milestone in breast US-OT imaging with many potential downstream clinical applications. Hence, we would like to present the first-in-human US-OT demonstration of lipid and collagen differentiation in an excised breast tissue from a 38-year-old female. |
| first_indexed | 2024-12-11T00:41:09Z |
| format | Article |
| id | doaj.art-87e55502607c4f39b14926b1fa208e4b |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-11T00:41:09Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-87e55502607c4f39b14926b1fa208e4b2022-12-22T01:26:54ZengElsevierPhotoacoustics2213-59792022-09-0127100377Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasoundYonggeng Goh0Ghayathri Balasundaram1Hui Min Tan2Thomas Choudary Putti3Siau Wei Tang4Celene Wei Qi Ng5Shaik Ahmad Buhari6Eric Fang7Mohesh Moothanchery8Renzhe Bi9Malini Olivo10Swee Tian Quek11Department of Diagnostic Imaging, National University Hospital, SingaporeTranslational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, SingaporeDepartment of Pathology, National University Hospital, SingaporeDepartment of Pathology, National University Hospital, SingaporeDepartment of Breast Surgery, National University Hospital, SingaporeDepartment of Breast Surgery, National University Hospital, SingaporeDepartment of Breast Surgery, National University Hospital, SingaporeDepartment of Diagnostic Imaging, National University Hospital, SingaporeTranslational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, SingaporeTranslational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, SingaporeTranslational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, Singapore; Correspondence to: Translational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, 11 Biopolis Way, #02–02 Helios, Singapore 138667, Singapore.Department of Diagnostic Imaging, National University Hospital, Singapore; Correspondence to: 5 Lower Kent Ridge Road, Singapore 119074, Singapore.To date, studies which utilized ultrasound (US) and optoacoustic tomography (OT) fusion (US-OT) in biochemical differentiation of malignant and benign breast conditions have relied on limited biochemical data such as oxyhaemoglobin (OH) and deoxyhaemoglobin (DH) only. There has been no data of the largest biochemical components of breast fibroglandular tissue: lipid and collagen. Here, the authors believe the ability to image collagen and lipids within the breast tissue could serve as an important milestone in breast US-OT imaging with many potential downstream clinical applications. Hence, we would like to present the first-in-human US-OT demonstration of lipid and collagen differentiation in an excised breast tissue from a 38-year-old female.http://www.sciencedirect.com/science/article/pii/S2213597922000428CollagenLipidBreastOptoacousticTomography |
| spellingShingle | Yonggeng Goh Ghayathri Balasundaram Hui Min Tan Thomas Choudary Putti Siau Wei Tang Celene Wei Qi Ng Shaik Ahmad Buhari Eric Fang Mohesh Moothanchery Renzhe Bi Malini Olivo Swee Tian Quek Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound Photoacoustics Collagen Lipid Breast Optoacoustic Tomography |
| title | Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound |
| title_full | Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound |
| title_fullStr | Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound |
| title_full_unstemmed | Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound |
| title_short | Biochemical “decoding” of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound |
| title_sort | biochemical decoding of breast ultrasound images with optoacoustic tomography fusion first in human display of lipid and collagen signals on breast ultrasound |
| topic | Collagen Lipid Breast Optoacoustic Tomography |
| url | http://www.sciencedirect.com/science/article/pii/S2213597922000428 |
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