IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19
Introduction: Since the Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, on 12 December 2019, it has spread rapidly across the world and developed into a pandemic. As healthcare workers are frequently in contact with Coronavirus disease-2019 (COVID-19) patients, t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Turkish |
| Published: |
Galenos Yayinevi
2022-05-01
|
| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | http://www.mjima.org/text.php?&id=317 |
| _version_ | 1797908759430823936 |
|---|---|
| author | Hasan YEŞİLAĞAÇ Hikmet Eda ALIŞKAN Hatice Hale GÜMÜŞ İlker ÖDEMİŞ Zuhal EKİCİ ÜNSAL |
| author_facet | Hasan YEŞİLAĞAÇ Hikmet Eda ALIŞKAN Hatice Hale GÜMÜŞ İlker ÖDEMİŞ Zuhal EKİCİ ÜNSAL |
| author_sort | Hasan YEŞİLAĞAÇ |
| collection | DOAJ |
| description | Introduction: Since the Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, on 12 December 2019, it has spread rapidly across the world and developed into a pandemic. As healthcare workers are frequently in contact with Coronavirus disease-2019 (COVID-19) patients, they can be affected more often than the general population. In this study we aimed to investigate the SARS-CoV-2 seroprevalence and the IgG antibody levels among healthcare workers who frequently encountered COVID-19 patients in our hospital.
Materials and Methods: In total, 182 healthcare workers were identified from database and their data was retrospectively analyzed. Participants with previous PCR positivity, pregnant, autoimmune disease history or immunosuppressive treatment history were excluded. Participants were grouped depending on their frequency of contact with COVID-19 patients (high and medium risk). All the samples were tested simultaneously for anti-SARS-CoV-2-IgG antibodies by the ELISA method. A chi-square test was used to compare categorical variables. A t-test and an ANOVA test were carried out to where appropriate.
Results: Serological testing of 182 HCWs exposed to SARS-CoV-2 patients illustrated that 13.2% of them (24 out of 182) might have experienced an asymptomatic or subclinical SARS-CoV-2 infection. High risk participants, anosmia, and ageusia were statistically significant risk factors. The rate of detection of antibody positivity among doctors (p=0.030) and patients with anosmia, and ageusia (p=0.047) were found significantly higher than the others. In addition, SARS-CoV-2 antibody ratio results were found significantly higher in the groups of high risk participants (p=0.046), patients with clinical signs (p=0.008), myalgia (p=0.039), anosmia, and ageusia (p=0.025), respectively.
Conclusion: Our study showed that serological testing is useful for determining asymptomatic or subclinical infections prevelance of SARS-CoV-2 among those with close contact with COVID-19 patients. Serological tests can be helpful determining the prevelance COVID-19 infection, especially among the HCWs. |
| first_indexed | 2024-04-10T10:57:36Z |
| format | Article |
| id | doaj.art-87e81eff170c4497be55c9a5c7e8a137 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T10:57:36Z |
| publishDate | 2022-05-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-87e81eff170c4497be55c9a5c7e8a1372023-02-15T16:19:51ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2022-05-0111110.4274/mjima.galenos.2022.2021.19IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19Hasan YEŞİLAĞAÇ0https://orcid.org/0000-0002-1365-9256Hikmet Eda ALIŞKAN1https://orcid.org/0000-0001-9060-3195Hatice Hale GÜMÜŞ2https://orcid.org/0000-0001-9071-9606İlker ÖDEMİŞ3https://orcid.org/0000-0003-2638-0163Zuhal EKİCİ ÜNSAL4https://orcid.org/0000-0003-3225-2686Başkent University Faculty of Medicine, Department of Emergency Medicine, Adana, TurkeyBaşkent University Faculty of Medicine, Department of Clinical Microbiology, Adana, TurkeyBaşkent University Faculty of Medicine, Department of Clinical Microbiology, Adana, TurkeyBaşkent University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Adana, TurkeyBaşkent University Faculty of Medicine, Department of Pulmonary Diseases, Adana, TurkeyIntroduction: Since the Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, on 12 December 2019, it has spread rapidly across the world and developed into a pandemic. As healthcare workers are frequently in contact with Coronavirus disease-2019 (COVID-19) patients, they can be affected more often than the general population. In this study we aimed to investigate the SARS-CoV-2 seroprevalence and the IgG antibody levels among healthcare workers who frequently encountered COVID-19 patients in our hospital. Materials and Methods: In total, 182 healthcare workers were identified from database and their data was retrospectively analyzed. Participants with previous PCR positivity, pregnant, autoimmune disease history or immunosuppressive treatment history were excluded. Participants were grouped depending on their frequency of contact with COVID-19 patients (high and medium risk). All the samples were tested simultaneously for anti-SARS-CoV-2-IgG antibodies by the ELISA method. A chi-square test was used to compare categorical variables. A t-test and an ANOVA test were carried out to where appropriate. Results: Serological testing of 182 HCWs exposed to SARS-CoV-2 patients illustrated that 13.2% of them (24 out of 182) might have experienced an asymptomatic or subclinical SARS-CoV-2 infection. High risk participants, anosmia, and ageusia were statistically significant risk factors. The rate of detection of antibody positivity among doctors (p=0.030) and patients with anosmia, and ageusia (p=0.047) were found significantly higher than the others. In addition, SARS-CoV-2 antibody ratio results were found significantly higher in the groups of high risk participants (p=0.046), patients with clinical signs (p=0.008), myalgia (p=0.039), anosmia, and ageusia (p=0.025), respectively. Conclusion: Our study showed that serological testing is useful for determining asymptomatic or subclinical infections prevelance of SARS-CoV-2 among those with close contact with COVID-19 patients. Serological tests can be helpful determining the prevelance COVID-19 infection, especially among the HCWs.http://www.mjima.org/text.php?&id=317covid-19healthcare workerspandemicsars-cov-2seroprevalance |
| spellingShingle | Hasan YEŞİLAĞAÇ Hikmet Eda ALIŞKAN Hatice Hale GÜMÜŞ İlker ÖDEMİŞ Zuhal EKİCİ ÜNSAL IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 Mediterranean Journal of Infection, Microbes and Antimicrobials covid-19 healthcare workers pandemic sars-cov-2 seroprevalance |
| title | IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 |
| title_full | IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 |
| title_fullStr | IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 |
| title_full_unstemmed | IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 |
| title_short | IgG Neutralizing Antibodies to SARS-CoV-2 Among Healthcare Workers Who Frequently Encountered Patients with COVID-19 |
| title_sort | igg neutralizing antibodies to sars cov 2 among healthcare workers who frequently encountered patients with covid 19 |
| topic | covid-19 healthcare workers pandemic sars-cov-2 seroprevalance |
| url | http://www.mjima.org/text.php?&id=317 |
| work_keys_str_mv | AT hasanyesilagac iggneutralizingantibodiestosarscov2amonghealthcareworkerswhofrequentlyencounteredpatientswithcovid19 AT hikmetedaaliskan iggneutralizingantibodiestosarscov2amonghealthcareworkerswhofrequentlyencounteredpatientswithcovid19 AT haticehalegumus iggneutralizingantibodiestosarscov2amonghealthcareworkerswhofrequentlyencounteredpatientswithcovid19 AT ilkerodemis iggneutralizingantibodiestosarscov2amonghealthcareworkerswhofrequentlyencounteredpatientswithcovid19 AT zuhalekiciunsal iggneutralizingantibodiestosarscov2amonghealthcareworkerswhofrequentlyencounteredpatientswithcovid19 |