Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy
AimThere are no prospective longitudinal studies on the association between well-controlled gestational diabetes mellitus (GDM) without pharmacologic therapy and the physical growth of offspring in infancy. We aimed to identify the trajectories in physical growth (from 0–12 months of age) in the off...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1063989/full |
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| author | Chao Li Chao Li Chao Li Yixi Cai Yinying Li Bin Peng Yongfang Liu Yongfang Liu Zhenming Wang Ting Yang Ting Yang Yirong Hu Yajun Fu Tingmei Shi Hong Peng Yue Zhang Jie Chen Jie Chen Tingyu Li Tingyu Li Li Chen Li Chen |
| author_facet | Chao Li Chao Li Chao Li Yixi Cai Yinying Li Bin Peng Yongfang Liu Yongfang Liu Zhenming Wang Ting Yang Ting Yang Yirong Hu Yajun Fu Tingmei Shi Hong Peng Yue Zhang Jie Chen Jie Chen Tingyu Li Tingyu Li Li Chen Li Chen |
| author_sort | Chao Li |
| collection | DOAJ |
| description | AimThere are no prospective longitudinal studies on the association between well-controlled gestational diabetes mellitus (GDM) without pharmacologic therapy and the physical growth of offspring in infancy. We aimed to identify the trajectories in physical growth (from 0–12 months of age) in the offspring of mothers with well-controlled GDM without pharmacologic therapy in a prospective cohort in China.MethodsThis study included 236 offspring of mothers with GDM and 369 offspring of mothers without GDM. Mothers with GDM were not on pharmacologic therapy. The length and weight of infants were measured at 0, 1, 3, 6, and 12 months. Linear mixed-effect models and linear mixed-effect models were applied.ResultsThe fully adjusted model showed that the weight-for-age z-score (WAZ), length-for-age z-score (LAZ), and BMI-for-age z-score (BMIZ) were similar at birth for the GDM and control groups. However, subsequent increases in WAZ and BMIZ for the GDM group lagged the increases for the control group at the subsequent periods of observation, 0–1, 0–6, and 0–12 months.ConclusionsWell-controlled GDM without pharmacologic therapy may normalize physical growth of offspring at birth and decelerate their weight gain in infancy. Whether glycemic control can mitigate the long-term effects of GDM on the growth trajectory in offspring remains unclear. |
| first_indexed | 2024-04-13T04:27:44Z |
| format | Article |
| id | doaj.art-87e91ce41f934f2e924b39d4af4bc861 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T04:27:44Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-87e91ce41f934f2e924b39d4af4bc8612022-12-22T03:02:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10639891063989Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancyChao Li0Chao Li1Chao Li2Yixi Cai3Yinying Li4Bin Peng5Yongfang Liu6Yongfang Liu7Zhenming Wang8Ting Yang9Ting Yang10Yirong Hu11Yajun Fu12Tingmei Shi13Hong Peng14Yue Zhang15Jie Chen16Jie Chen17Tingyu Li18Tingyu Li19Li Chen20Li Chen21Ministry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaSchool of Public Health and Management, Department of Health Statistics, Chongqing Medical University, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaDepartment of Child Health Care, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Department of Growth, Development, and Mental Health of Children and Adolescence Center, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaChongqing Key Laboratory of Child Health and Nutrition, Chongqing, ChinaAimThere are no prospective longitudinal studies on the association between well-controlled gestational diabetes mellitus (GDM) without pharmacologic therapy and the physical growth of offspring in infancy. We aimed to identify the trajectories in physical growth (from 0–12 months of age) in the offspring of mothers with well-controlled GDM without pharmacologic therapy in a prospective cohort in China.MethodsThis study included 236 offspring of mothers with GDM and 369 offspring of mothers without GDM. Mothers with GDM were not on pharmacologic therapy. The length and weight of infants were measured at 0, 1, 3, 6, and 12 months. Linear mixed-effect models and linear mixed-effect models were applied.ResultsThe fully adjusted model showed that the weight-for-age z-score (WAZ), length-for-age z-score (LAZ), and BMI-for-age z-score (BMIZ) were similar at birth for the GDM and control groups. However, subsequent increases in WAZ and BMIZ for the GDM group lagged the increases for the control group at the subsequent periods of observation, 0–1, 0–6, and 0–12 months.ConclusionsWell-controlled GDM without pharmacologic therapy may normalize physical growth of offspring at birth and decelerate their weight gain in infancy. Whether glycemic control can mitigate the long-term effects of GDM on the growth trajectory in offspring remains unclear.https://www.frontiersin.org/articles/10.3389/fendo.2022.1063989/fullgestational diabetes mellitusgrowthoffspringlifestyle managementglucose control |
| spellingShingle | Chao Li Chao Li Chao Li Yixi Cai Yinying Li Bin Peng Yongfang Liu Yongfang Liu Zhenming Wang Ting Yang Ting Yang Yirong Hu Yajun Fu Tingmei Shi Hong Peng Yue Zhang Jie Chen Jie Chen Tingyu Li Tingyu Li Li Chen Li Chen Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy Frontiers in Endocrinology gestational diabetes mellitus growth offspring lifestyle management glucose control |
| title | Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| title_full | Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| title_fullStr | Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| title_full_unstemmed | Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| title_short | Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| title_sort | well controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy |
| topic | gestational diabetes mellitus growth offspring lifestyle management glucose control |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1063989/full |
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