Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy
Background: To estimate the incidence of Acute Rheumatic Fever (ARF) in Tuscany, a region of Central Italy, evaluating the epidemiological impact of the new diagnostic guidelines, and to analyse our outcomes in the context of the Italian overview.Methods: A multicenter and retrospective study was co...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.746505/full |
| _version_ | 1819101047544610816 |
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| author | Antonino Maria Quintilio Alberio Filippo Pieroni Alessandro Di Gangi Susanna Cappelli Giulia Bini Sarah Abu-Rumeileh Alessandro Orsini Alice Bonuccelli Diego Peroni Nadia Assanta Carla Gaggiano Gabriele Simonini Rita Consolini |
| author_facet | Antonino Maria Quintilio Alberio Filippo Pieroni Alessandro Di Gangi Susanna Cappelli Giulia Bini Sarah Abu-Rumeileh Alessandro Orsini Alice Bonuccelli Diego Peroni Nadia Assanta Carla Gaggiano Gabriele Simonini Rita Consolini |
| author_sort | Antonino Maria Quintilio Alberio |
| collection | DOAJ |
| description | Background: To estimate the incidence of Acute Rheumatic Fever (ARF) in Tuscany, a region of Central Italy, evaluating the epidemiological impact of the new diagnostic guidelines, and to analyse our outcomes in the context of the Italian overview.Methods: A multicenter and retrospective study was conducted involving children <18 years old living in Tuscany and diagnosed in the period between 2010 and 2019. Two groups were established based on the new diagnostic criteria: High-Risk (HR) group patients, n = 29 and Low-Risk group patients, n = 96.Results: ARF annual incidence ranged from 0.91 to 7.33 out of 100,000 children in the analyzed period, with peak of incidence registered in 2019. The application of HR criteria led to an increase of ARF diagnosis of 30%. Among the overall cohort joint involvement was the most represented criteria (68%), followed by carditis (58%). High prevalence of subclinical carditis was observed (59%).Conclusions: Tuscany should be considered an HR geographic area and HR criteria should be used for ARF diagnosis in this region. |
| first_indexed | 2024-12-22T01:12:27Z |
| format | Article |
| id | doaj.art-87ea495baa974eb0b1ecffca8461f5fe |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-22T01:12:27Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-87ea495baa974eb0b1ecffca8461f5fe2022-12-21T18:43:56ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-12-01910.3389/fped.2021.746505746505Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in ItalyAntonino Maria Quintilio Alberio0Filippo Pieroni1Alessandro Di Gangi2Susanna Cappelli3Giulia Bini4Sarah Abu-Rumeileh5Alessandro Orsini6Alice Bonuccelli7Diego Peroni8Nadia Assanta9Carla Gaggiano10Gabriele Simonini11Rita Consolini12Pediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyRheumatology Unit, Meyer Children's Hospital, University of Florence, Florence, ItalyPediatrics Unit, Section of Pediatric Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Section of Pediatric Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyPediatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyHeart Hospital-G. Monasterio Tuscany Foundation, Massa, ItalyClinical Pediatrics, Department of Molecular Medicine and Development, University of Siena, Siena, ItalyRheumatology Unit, Meyer Children's Hospital, University of Florence, Florence, ItalyPediatrics Unit, Section of Clinical and Laboratory Immunology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyBackground: To estimate the incidence of Acute Rheumatic Fever (ARF) in Tuscany, a region of Central Italy, evaluating the epidemiological impact of the new diagnostic guidelines, and to analyse our outcomes in the context of the Italian overview.Methods: A multicenter and retrospective study was conducted involving children <18 years old living in Tuscany and diagnosed in the period between 2010 and 2019. Two groups were established based on the new diagnostic criteria: High-Risk (HR) group patients, n = 29 and Low-Risk group patients, n = 96.Results: ARF annual incidence ranged from 0.91 to 7.33 out of 100,000 children in the analyzed period, with peak of incidence registered in 2019. The application of HR criteria led to an increase of ARF diagnosis of 30%. Among the overall cohort joint involvement was the most represented criteria (68%), followed by carditis (58%). High prevalence of subclinical carditis was observed (59%).Conclusions: Tuscany should be considered an HR geographic area and HR criteria should be used for ARF diagnosis in this region.https://www.frontiersin.org/articles/10.3389/fped.2021.746505/fullacute rheumatic feverepidemiologyrevised Jones criteriahigh-risk populationincidence |
| spellingShingle | Antonino Maria Quintilio Alberio Filippo Pieroni Alessandro Di Gangi Susanna Cappelli Giulia Bini Sarah Abu-Rumeileh Alessandro Orsini Alice Bonuccelli Diego Peroni Nadia Assanta Carla Gaggiano Gabriele Simonini Rita Consolini Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy Frontiers in Pediatrics acute rheumatic fever epidemiology revised Jones criteria high-risk population incidence |
| title | Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy |
| title_full | Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy |
| title_fullStr | Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy |
| title_full_unstemmed | Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy |
| title_short | Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy |
| title_sort | toward the knowledge of the epidemiological impact of acute rheumatic fever in italy |
| topic | acute rheumatic fever epidemiology revised Jones criteria high-risk population incidence |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.746505/full |
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