Target DNA structure plays a critical role in RAG transposition.

Target DNA structure plays a critical role in RAG transposition.

Antigen receptor gene rearrangements are initiated by the RAG1/2 protein complex, which recognizes specific DNA sequences termed RSS (recombination signal sequences). The RAG recombinase can also catalyze transposition: integration of a DNA segment bounded by RSS into an unrelated DNA target. For re...

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Bibliographic Details
Main Authors: Jennifer E Posey, Malgorzata J Pytlos, Richard R Sinden, David B Roth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1618415?pdf=render

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http://europepmc.org/articles/PMC1618415?pdf=render

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